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Single-cell RNA sequencing of human fallopian tubes from benign donors

ABSTRACT: Single-cell RNA sequencing of human fallopian tubes from benign donors

PROVIDER: PRJNA578284 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10307700.fastq.gz	Fastqsanger.gz
	SRR10307800.fastq.gz	Fastqsanger.gz
	SRR10307900.fastq.gz	Fastqsanger.gz
	SRR10308000.fastq.gz	Fastqsanger.gz
	SRR10308100.fastq.gz	Fastqsanger.gz

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Single-cell RNA sequencing of human fallopian tubes

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Single-cell RNA sequencing of human fallopian tubes from benign donors

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Project description:Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive system. In order to improve EOC patient outcomes, it is crucial to have a better understanding of how EOC develops from its cellular origin. EOCs can originate from either fallopian tube epithelial (FTE) cells or ovarian surface epithelial (OSE) cells, but with different courses of development. The basis for this difference is unclear. To address this, we performed single cell RNA-sequencing of mouse cells isolated from the distal portion of fallopian tubes (i.e., oviducts) and surface layer of ovaries. Analysis of this single cell dataset revealed distinct niche organizations for murine FTE cells and OSE cells.

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Chlamydia trachomatis serogroup D disturbs epithelial tissue homeostasis in Fallopian tubes via paracrine Wnt signalling

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scRNA-seq analysis of hydrosalphinx disease state Vs healthy state of human fallopian tubes

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