Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Agromyces agglutinans strain:CFH 90414

ABSTRACT: Agromyces sp. CFH 90414 ,whole genome shotgun sequensing project

PROVIDER: PRJNA579325 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cohnella sp. CFH 77786

Project description:CFH 77786 Cohnella sp. whole genome shotgun sequensing project

| PRJNA579324 | ENA

Lysobacter sp. CFH 32150

Project description:Lysobacter. sp CFH 32150 whole genome shotgun sequensing project

| PRJNA816813 | ENA

Nocardioides sp. CFH 31398

Project description:Nocardioides sp. CFH 31398 , whole genome shotgun sequensing project

| PRJNA809078 | ENA

Paracoccus luteus strain:CFH 10530

Project description:Paracoccus sp CFH 10530T, Whole genome Shotgun sequencing project

| PRJNA513413 | ENA

Microbacterium sp. CFH 31415

Project description:Microbacterium sp.CFH 31415, whole genome shotgun sequensing project

| PRJNA810787 | ENA

Microbacterium salsuginis strain:CFH 90308

Project description:Microbacterium sp.CFH 90308 ,whole genome shotgun sequensing project

| PRJNA623857 | ENA

Prescottella agglutinans strain:CFH S0262

Project description:Rhodococcus agglutinans CFH S0262 genome sequencing

| PRJNA834312 | ENA

Agromyces

Project description:Agromyces sp. overview

| PRJNA330874 | ENA

Paucibacter sp. XJ19-41

Project description:Paucibacter sp. XJ19-41, whole genome shotgun sequensing project

| PRJNA928862 | ENA

Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants

Project description:Complement Factor H (CFH) common genetic variants have been associated with age-related macular degeneration (AMD). While most previous in vitro RPE studies focused on the common p.His402Tyr CFH variant, we characterized rare CFH variants that are highly penetrant for AMD using induced pluripotent stem cell derived retinal pigment epithelium (iPSC-RPE). Our results show that lower FH levels were detected in AMD RPE, which potentially disrupted canonical and non-canonical roles of FH. Specifically, AMD RPE displayed higher inflammation rate and a reduced set of differentially expressed genes compared to control RPE upon A2E and blue light challenge. Additionally, cholesterol efflux and POS phagocytosis defects, dysregulated complement levels, larger sub-RPE deposits and increased mitochondrial stress were observed in AMD RPE. Thus, our study reveals new non-canonical roles for FH in regulating important RPE functions.

2024-12-02 | GSE275494 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data