Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CD4+ T cell subsets in LCMV infection and KLH-gp61 immunization

ABSTRACT: CD4+ T cell subsets in LCMV infection and KLH-gp61 immunization

PROVIDER: PRJNA588644 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10087400.fastq.gz	Fastqsanger.gz
	SRR10087500.fastq.gz	Fastqsanger.gz
	SRR10087401.fastq.gz	Fastqsanger.gz
	SRR10087501.fastq.gz	Fastqsanger.gz
	SRR10087402.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 248

Similar Datasets

RNA-seq of CD4+ T cell subsets in KLH-gp61 immunization

Project description:RNA-seq of CD4+ T cell subsets in KLH-gp61 immunization

| PRJNA564588 | ENA

CD4+ T cell subsets during LCMV infection

Project description:CD4+ T cell subsets during LCMV infection

| PRJNA763824 | ENA

Expression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection

Project description:CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ subpopulations (based on CXCR5 and Ly6c expression)in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to the Tfh and Th1 lineages. Our conclusions are based on gene expression profiles, epigenetic studies and phenotypic and functional analysis. The gene expression profiles of virus-specific CD4 T cell subets at effector and memory stages is presented here. The SMARTA TCR transgenic / adptive transfer system was used to identify and sort subsets of antigen-specific CD4 T cells (based on their expression of Ly6c and CXCR5) elicited after acute infection with LCMV (Arm).

2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress

Vaccine-Elicited CD4 T Cells Induce Immunopathology Following Chronic LCMV Infection

Project description:CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. Here we evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality following challenge with a persistent form of LCMV. Immunopathology required antigen-specific CD4 T cells and was associated with a cytokine storm, generalized inflammation, and multi-organ system failure. Virus-specific CD8 T cells or antibodies abrogated the pathology. These data demonstrate that vaccine-elicited CD4 T cells in the absence of effective antiviral immune responses can trigger lethal immunopathology. Splenic GP66-specific CD4 T cells from mice immunized with either a LMwt vaccine (sham) or LMgp61 vaccine (CD4 vaccine) were purified by FACS on day 8 post-infection with LCMV clone 13

2014-12-04 | E-GEOD-63825 | biostudies-arrayexpress

CD4+ T cell subsets in LCMV infection and KLH-gp61 immunization

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-03 | GSE140187 | GEO

ATAC-Seq of CD4+ T cell subsets during LCMV infection

Project description:ATAC-Seq of CD4+ T cell subsets during LCMV infection

| PRJNA763854 | ENA

ATAC-seq of CD4+ T cell subsets in LCMV infection

Project description:ATAC-seq of CD4+ T cell subsets in LCMV infection

| PRJNA565269 | ENA

RNA-seq of CD4+ T cell subsets in LCMV infection

Project description:RNA-seq of CD4+ T cell subsets in LCMV infection

| PRJNA564587 | ENA

ATAC-Seq of CD4+ T cell subsets during LCMV infection

Project description:Following an infection, CD4+ lymphocytes can differentiate into long-lived memory T cells, some of which circulate through the secondary lymphoid organs (SLOs) while a population lodges in non-lymphoid tissues. While CD4+ T cells in SLOs have been examined, the developmental origins and transcriptional regulation of tissue-resident memory T cells (TRM) remain largely undefined. Here, we investigated the phenotypic, functional, and transcriptional profile of virus-specific CD4+ TRM in the small intestine (SI) following acute lymphocytic choriomeningitis virus (LCMV) infection. LCMV-specific CD4+ TRM at day 7 of infection shared a gene-expression program and chromatin profile with TH1 cells and progressively acquired a mature TRM program by day 21 memory time point, supporting a developmental relationship between TRM and TH1 subsets. Furthermore, we demonstrated that TRM cells expressed genes associated with both effector and memory T cell fates, including the transcriptional regulators Blimp1, Id2, and Bcl6 which were necessary for CD4+ TRM differentiation. TH1-associated Blimp1 and Id2 were both required for early TRM formation, while TFH-associated Bcl6 initially inhibited TRM differentiation but was critical for development of long-lived TRM cells. Our results identify new significance for TFs previously associated with circulating CD4+ T cell populations and their roles in driving SI CD4+ TRM differentiation.

2023-06-30 | GSE184260 | GEO

RNA-Seq of wild-type CD4+ T cell subsets during LCMV infection

2023-06-30 | GSE184262 | GEO