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MiRNA profiling of peripheral blood mononuclear cells from AIDS patients and healthy control group

ABSTRACT: miRNA profiling of peripheral blood mononuclear cells from AIDS patients and healthy control group

PROVIDER: PRJNA590459 | ENA |

REPOSITORIES: ENA

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miRNA profiling of peripheral blood mononuclear cells from AIDS patients and healthy control group

Project description:With the purpose of identifying the cascaded miRNA-mRNA regulatory relationships related to infection of HIV in gene level, we extracted mRNA from Peripheral blood mononuclear cells from 50 AIDS patients and 7 uninfected health controls. All AIDS patients in sample were received Antiretroviral Therapy. To further analysis the miRNA expression pattern in different virus load, we classified high virus loads (HVL, n=14) and low virus loads (LVL, n=16). 145 and 129 differentially expressed miRNAs (DEMs) were selected, respectively in LVL and HVL. Functional enrichment analysis indicated miRNA-correlated targets which involved in immune response and apoptosis, played a crucial role in HIV infection. Further, we identified 5 most influential TFs to build miRNA-TF-mRNA regulatory network.

2021-11-10 | GSE140650 | GEO

Comparison of transcriptional profiles of peripheral blood mononuclear cells from AIDS patients and healthy control group

Project description:With the purpose of identifying the cascaded miRNA-mRNA regulatory relationships related to infection of HIV in gene level, we extracted mRNA from Peripheral blood mononuclear cells from 50 AIDS patients and 7 uninfected health controls. All AIDS patients in sample were received Antiretroviral Therapy. To further analysis the gene expression pattern in different virus load, we classified high virus loads (HVL, n=14) and low virus loads (LVL, n=16). 2635 and 2826 differentially expressed genes (DEGs) were selected, respectively in LVL and HVL. Functional enrichment analysis indicated DEGs which involved in immune response and apoptosis, played a crucial role in HIV infection. Further, we identified 5 most influential TFs to build miRNA-TF-mRNA regulatory network.

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Comparison of transcriptional profiles of peripheral blood mononuclear cells from AIDS patients and healthy control group

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