Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of hepatic mRNA in mice fed chow with and without the PAI-1 inhibitor TM5614

ABSTRACT: RNA-seq of hepatic mRNA in mice fed chow with and without the PAI-1 inhibitor TM5614

PROVIDER: PRJNA590695 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10502500.fastq.gz	Fastqsanger.gz
	SRR10502501.fastq.gz	Fastqsanger.gz
	SRR10502502.fastq.gz	Fastqsanger.gz
	SRR10502503.fastq.gz	Fastqsanger.gz
	SRR10502504.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

RNA-seq of hepatic mRNA in mice fed chow with and without the PAI-1 inhibitor TM5614

Project description:We report RNA-seq data from hepatic mRNA in mice on standard chow. Mice 41-45 were fed standard chow. Mice 46-50 were fed standard chow + a PAI-1 inhibitor, TM5614 for 10 days.

2020-11-01 | GSE140725 | GEO

RNA-seq of hepatic mRNA from 21 week old PAI-1 +/- and littermate control mice fed standard chow

Project description:We report RNA-seq data from hepatic mRNA on WT and PAI-1 heterozygous 21 week old mice.

2020-11-01 | GSE151597 | GEO

RNA-seq of hepatic mRNA from 21 week old PAI-1 +/- and littermate control mice fed standard chow

Project description:RNA-seq of hepatic mRNA from 21 week old PAI-1 +/- and littermate control mice fed standard chow

| PRJNA636505 | ENA

Liver-specific matrin-3 knockout alters the hepatic transcriptome of chow diet-fed mice [RNA-seq]

Project description:Matrin-3 is an RNA-binding protein involved in the pathogenesis of human diseases. Here we examined the hepatic transcriptome of chow-diet fed mice. Bulk RNA-seq and bioinformatics analysis identified 646 and 145 differentially expressed genes (Padj < 0.05), respectively in the livers of female and male matrin-3 LKO mice. Enrichr analysis of these DEGs revealed several common Hallmark terms including cholesterol homeostasis, fatty acid metabolism, xenobiotic metabolism, and epithelial mesenchymal transition between female and male mice. Our data demonstrated that liver-specific matrin-3 deficiency re-programs the hepatic transcriptome in the liver of chow diet-fed mice.

2024-10-01 | GSE267224 | GEO

Hepatic gene expression in wild type and SHPKO mice fed chow or western diet

Project description:SHP (small heterodimer partner; NR0B2) belongs to the nuclear hormone receptor superfamily, which regulates numerous developmental and metabolic cellular functions. To study physiological function of SHP, we generated congenic SHP-/- mice on C57Bl/6 background. When the congenic SHP-/- mice were challenged with a western diet (harlan, TD.88137) for 22 weeks, they were resistant to diet induced obesity and hepatic steatosis compared to WT controls. However, their hepatic insulin sensitivity was compromised when assessed with phospho-Akt levels after insulin injection. Therefore, we investigated hepatic gene expression using illumina beadchip array to explore mechanisms underneath the unique liver physiology in SHP-/- mice. Livers were collected from C57Bl/6 wild type and C57Bl/6 SHP-/- mice fed chow or western diet. The 1 microgram of total RNA obtained from individual mouse (n=4 per group) and subjected to illumina beadchip gene expression profiling.

2012-05-16 | E-GEOD-38013 | biostudies-arrayexpress

Global hepatic transcript data from fed male BXD strains on chow or high fat diet

Project description:Gene expression levels assessed by microarray in liver samples collected from the BXD mouse genetic diversity model fed either a standard chow or a high fat diet at a fed state.

2022-09-27 | GSE188764 | GEO

Rat Liver HFD vs Chow, HFD vs PKCepsilon ASO

Project description:Insulin resistance drives the development of type 2 diabetes (T2D). In liver, diacylglycerol (DAG) is a key mediator of lipid-induced insulin resistance. DAG activates protein kinase C epsilon (PKCÎµ), which phosphorylates and inhibits the insulin receptor. In rats, a 3-day high fat diet produces hepatic insulin resistance through this mechanism, and knockdown of hepatic PKCÎµ protects against high fat diet-induced hepatic insulin resistance. Here we employ a systems level approach to uncover additional signaling pathways involved in high fat diet-induced hepatic insulin resistance. We used quantitative phosphoproteomics to map global in vivo changes in hepatic protein phosphorylation in chow-fed, high fat-fed, and high fat-fed with PKCÎµ knockdown rats to distinguish the impact of lipid- and PKCÎµ-induced protein phosphorylation.

2018-08-30 | PXD010209 | Pride

Translation efficiency in the mouse liver upon 24h chow or ketogenic diet fed

Project description:To investigate the translatome in the ketogenic diet fed condition and the role of phosphoralated eIF4E in it We performed polysome sequencing on chow fed and 24h ketogenic diet fed wild type mice and chow fed eIF4E S209A/S209A mice

2024-08-14 | GSE267336 | GEO

Differential gene expression in HFD-fed mouse liver

Project description:Hepatic expression of genes in chow-fed and HFD-fed mice were compared.

2022-04-20 | GSE201044 | GEO

Effect of Fumonisin B1 exposure on hepatic gene expression in mice fed a regular diet (CHOW) and in mice fed a High Fat Diet (HFD).

Project description:This experiment was designed to investigate the effect of Fumonisin B1 exposure on liver gene expression in male mice fed a regular diet (Chow group) and in obese mice which were fed a High fat diet (HFD). The Fumonisin B1 was provided through the drinking water.

2023-09-01 | GSE208735 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data