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RNA-seq of hepatic mRNA in mice fed chow with and without the PAI-1 inhibitor TM5614

ABSTRACT: RNA-seq of hepatic mRNA in mice fed chow with and without the PAI-1 inhibitor TM5614

PROVIDER: PRJNA590695 | ENA |

REPOSITORIES: ENA

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RNA-seq of hepatic mRNA in mice fed chow with and without the PAI-1 inhibitor TM5614

Project description:We report RNA-seq data from hepatic mRNA in mice on standard chow. Mice 41-45 were fed standard chow. Mice 46-50 were fed standard chow + a PAI-1 inhibitor, TM5614 for 10 days.

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RNA-seq of hepatic mRNA from 21 week old PAI-1 +/- and littermate control mice fed standard chow

Project description:RNA-seq of hepatic mRNA from 21 week old PAI-1 +/- and littermate control mice fed standard chow

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Liver-specific matrin-3 knockout alters the hepatic transcriptome of chow diet-fed mice [RNA-seq]

Project description:Matrin-3 is an RNA-binding protein involved in the pathogenesis of human diseases. Here we examined the hepatic transcriptome of chow-diet fed mice. Bulk RNA-seq and bioinformatics analysis identified 646 and 145 differentially expressed genes (Padj < 0.05), respectively in the livers of female and male matrin-3 LKO mice. Enrichr analysis of these DEGs revealed several common Hallmark terms including cholesterol homeostasis, fatty acid metabolism, xenobiotic metabolism, and epithelial mesenchymal transition between female and male mice. Our data demonstrated that liver-specific matrin-3 deficiency re-programs the hepatic transcriptome in the liver of chow diet-fed mice.

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Hepatic gene expression in wild type and SHPKO mice fed chow or western diet

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Project description:Gene expression levels assessed by microarray in liver samples collected from the BXD mouse genetic diversity model fed either a standard chow or a high fat diet at a fed state.

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Rat Liver HFD vs Chow, HFD vs PKCepsilon ASO

Project description:Insulin resistance drives the development of type 2 diabetes (T2D). In liver, diacylglycerol (DAG) is a key mediator of lipid-induced insulin resistance. DAG activates protein kinase C epsilon (PKCÎµ), which phosphorylates and inhibits the insulin receptor. In rats, a 3-day high fat diet produces hepatic insulin resistance through this mechanism, and knockdown of hepatic PKCÎµ protects against high fat diet-induced hepatic insulin resistance. Here we employ a systems level approach to uncover additional signaling pathways involved in high fat diet-induced hepatic insulin resistance. We used quantitative phosphoproteomics to map global in vivo changes in hepatic protein phosphorylation in chow-fed, high fat-fed, and high fat-fed with PKCÎµ knockdown rats to distinguish the impact of lipid- and PKCÎµ-induced protein phosphorylation.

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Project description:To investigate the translatome in the ketogenic diet fed condition and the role of phosphoralated eIF4E in it We performed polysome sequencing on chow fed and 24h ketogenic diet fed wild type mice and chow fed eIF4E S209A/S209A mice

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Differential gene expression in HFD-fed mouse liver

Project description:Hepatic expression of genes in chow-fed and HFD-fed mice were compared.

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