Project description:The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning we conducted detailed transcriptional profiling during embryonic development of the mouse brain. 2400 genes were identified as showing differential expression between three developmental stages. Analysis of the data identified nine gene clusters to demonstrate analogous expression profiles. A significant group of novel genes of as yet undiscovered biological function were detected, as being potentially relevant to brain development and function, in addition to genes that have previously identified roles in the brain. Analysis of left-right asymmetry of expression revealed 35 genes as putatively asymmetric from a combined data set. Our data constitutes a valuable new resource for neuroscience and neuro-development, exposing possible functional associations between genes, including novel loci, and encouraging their further investigation in human neurological and behavioural disorders. Whole genome transcriptional profiling carried out on 24 samples during 3 stages of embryonic development of the mouse brain was carried out with matching left-right asymmetry on four biological replicates at each stage.

2014-03-01 | E-GEOD-44932 | biostudies-arrayexpress

RNA-seq of Barrelette neurons and progenitors during mouse brain development

Project description:RNA-seq of Barrelette neurons and progenitors during mouse brain development

| PRJEB34371 | ENA

miRNAs expression patterns during mouse retina development

Project description:miRNAs expression patterns during mouse retina development

| PRJNA475535 | ENA

Gene expression data from mouse postnatal brain development

Project description:In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. We measured the timing of gene expression changes in the brains of two species of mice throughout postnatal development. Mus musculus and Mus spretus mice were bred at the MPI-EVA mouse facility. Whole brain samples were collected from mice of 3 different age classes: newborns, pups and young adults. RNA extracted from the dissected tissue was hybridized to Affymetrix MG-430 2.0 GeneChip arrays.

2009-03-09 | E-GEOD-11528 | biostudies-arrayexpress

Ribosome profiling analysis of mouse brain neocortex during development

Project description:We perform Ribosome Profiling (Ribo-seq) analysis of mouse brain neocortex during development embyonic days 12.5, 14, 15.5, 17, and postnatal day 0 in biological duplicate

2022-09-06 | GSE169457 | GEO

Global epigenomic reconfiguration during mammalian brain development

Project description:Global epigenomic reconfiguration during mammalian brain development

| PRJNA208503 | ENA