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Long-term absence of Langerhans cells alters the gene expression 2 profile of keratinocytes and dendritic epidermal T cells

ABSTRACT: Long-term absence of Langerhans cells alters the gene expression 2 profile of keratinocytes and dendritic epidermal T cells

PROVIDER: PRJNA591163 | ENA |

REPOSITORIES: ENA

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Long-term absence of Langerhans cells alters the gene expression 2 profile of keratinocytes and dendritic epidermal T cells

Project description:In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells (LCs) led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells

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Human epidermal keratinocytes treated with retinoic acid or thyroid hormone

Project description:Targets of Retinoic Acid (RA) were identified in primary human epidermal keratinocytes grown in the presence or absence of all-trans retinoic acid for 1, 4, 24, 48 and 72 hours. Targets of Thyroid Hormone (T3) were identified in primary human epidermal keratinocytes grown in the presence or absence of the hormone; same controls as for RA.

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Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells.

Project description:Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation.

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Project description:In an HPV-induced hyperplastic epithelium mouse model, hyperproliferative Keratinocytes (KCs) showed reduced Interleukin 34 (IL34) expression and chromatin accessibility, associating disturbing cell-cell interaction and immune response genes. Correspondingly, Langerhans cells (LCs) exhibited altered chromatin accessibility, including increased accessibility of IL34's receptor - the colony-stimulating factor 1 receptor (Csf1r) and reduced accessibility in antigen uptake and presentation genes.

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