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ChIP-seq analysis of wild-type or PAC1-/- T cells with anti-H3K27-ac

ABSTRACT: ChIP-seq analysis of wild-type or PAC1-/- T cells with anti-H3K27-ac

PROVIDER: PRJNA592972 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10574100_1.fastq.gz	Fastqsanger.gz
	SRR10574100_2.fastq.gz	Fastqsanger.gz
	SRR10574101_1.fastq.gz	Fastqsanger.gz
	SRR10574101_2.fastq.gz	Fastqsanger.gz
	SRR10574102_1.fastq.gz	Fastqsanger.gz

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ChIP-seq analysis of wild-type or PAC1-/- T cells with anti-H3K27-ac

Project description:To analyze the effects of PAC1 on acetylation of H3K27 in exhausted CD8+ T cells, we isolated CD8+ T cells from spleen of wild-type or PAC1-/- mice post LCMV Cl13 infection and performed ChIP-seq with anti-H3K27-ac.

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Project description:LPS-stimulated macrophages from Pac1+/+ and Pac1-/- mice were compared to assess gene expression changes in the absence of PAC-1 (also known as Dual specificity phosphatase 2). Experiment Overall Design: Age matched Pac1+/+ and Pac1-/- littermates were used to obtain equal numbers of thiolycollate-elicited macrophages. Pure populations of macrophages were stimulated with 100 ng/ml of LPS for 6 hours. 6 hours was chosen to assess mainly inflammatory gene expression.

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