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Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers? [RNA-seq]

ABSTRACT: Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers? [RNA-seq]

PROVIDER: PRJNA593212 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10582112.fastq.gz	Fastqsanger.gz
	SRR10582113.fastq.gz	Fastqsanger.gz
	SRR10582114.fastq.gz	Fastqsanger.gz
	SRR10582115.fastq.gz	Fastqsanger.gz
	SRR10582116.fastq.gz	Fastqsanger.gz

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Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers?

Project description:Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers?

| PRJNA593506 | ENA

Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers? [miRNA-seq]

Project description:Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers? [miRNA-seq]

| PRJNA593513 | ENA

Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers? [RNA-seq]

Project description:The signal for maternal recognition of pregnancy (MRP) has still not been identified in the horse. Endometrial biopsies, uterine fluid, embryonic tissues and yolk sac fluid were collected 13 days after ovulation during pregnant and control cycles from the same mares. Micro-RNA-Sequencing was performed on all collected samples and mRNA-Sequencing was conducted on the same endometrial and embryonic tissue samples

2020-02-24 | GSE141360 | GEO

Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers? [miRNA-seq]

2020-02-24 | GSE141443 | GEO

Maternal Recognition of Pregnancy in the Horse: Are MicroRNAs the Secret Messengers?

Project description:The signal for maternal recognition of pregnancy (MRP) has still not been identified in the horse. High-throughput molecular biology at the embryo-maternal interface has substantially contributed to the knowledge on pathways affected during MRP, but an integrated study in which proteomics, transcriptomics and miRNA expression can be linked directly is currently lacking. The aim of this study was to provide such analysis. Endometrial biopsies, uterine fluid, embryonic tissues, and yolk sac fluid were collected 13 days after ovulation during pregnant and control cycles from the same mares. Micro-RNA-Sequencing was performed on all collected samples, mRNA-Sequencing on the same tissue samples and mass spectrometry was conducted previously on the same fluid samples. Differential expression of miRNA, mRNA and proteins showed high conformity with literature and confirmed involvement in pregnancy establishment, embryo quality, steroid synthesis and prostaglandin regulation, but the link between differential miRNAs and their targets was limited and did not indicate the identity of an unequivocal signal for MRP in the horse. Differential expression at the embryo-maternal interface was prominent, highlighting a potential role of miRNAs in embryo-maternal communication during early pregnancy in the horse. These data provide a strong basis for future targeted studies.

| S-EPMC7014256 | biostudies-literature

Maternal recognition of pregnancy in the horse: are microRNAs the secret messengers?

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-02-24 | GSE141450 | GEO

Transcriptome profile of the anterior pituitary gland in pigs during maternal recognition of pregnancy

Project description:The knowledge regarding the reproductive-status-related changes occurring within the transcriptome of the porcine pituitary is limited. This study aimed to compare pituitary gland gene expression profiles of pigs during the maternal recognition of pregnancy period (days 12-13 of pregnancy) with pigs during the respective days of the estrous cycle using a microarray approach. Analysis indicated 482 differentially expressed genes (DEGs) with a FC ≥ 1.5 (p < 0.05) in the pituitary of pregnant vs. estrous-cyclic pigs. Among them, 68 were up-regulated and 414 were down-regulated. The evaluated DEGs were annotated to 39 gene ontology (GO) biological processes terms, 13 GO cellular components terms, and 10 GO molecular function terms. Among the evaluated DEGs were selected genes coding for proteins potentially involved in the regulation of early pregnancy in pigs and used for gene interaction analysis and validation of microarray results. Analysis of the relationships among DEGs during maternal recognition of pregnancy showed that some of them are connected with, i.e., TGFβ signaling pathway, follicle-stimulating hormone, prolactin, and growth hormone synthesis or activity, adipocytokines responsivity, angiogenesis, immune response, prostaglandin synthesis and inter-pituitary cell to cell interactions. The findings expand the knowledge regarding the molecular mechanisms appearing in the pituitary in pigs during the maternal recognition period of pregnancy.

2021-03-11 | GSE168615 | GEO

RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation

Project description:Successful establishment and maintenance of pregnancy can be attained only through optimum conceptus-maternal cross talk. Despite significant progress in our understanding of the temporal changes in the transcriptome of the uterine endometrium, we have only a rudimentary knowledge of the genes and pathways governing growth and development of the bovine conceptus. In particular, very little information exists for the posthatchingembryo and elongating conceptus. This period of development is arguably the most important, as approximately 40% of all embryonic loss occurs between Days 8 and 17 of pregnancy in cattle. Here, we describe the global transcriptome profile of the bovine conceptus at five key stages of its pre- and peri-implantation growth (Days 7, 10, 13, 16, and 19) using state-of-the-art RNA sequencing techniques. More than 287 million reads were generated at the five stages, and more than 22?700 unique transcripts were detected. Analysis of variance followed by self-organizing maps identified differentially regulated (P < 0.05) genes organized in nine gene clusters forming a sequential transcript dynamics across these developmental stages. Of particular interest, genes in clusters 3 (n = 236) and 6 (n = 1409) were significantly up-regulated on Days 16 and 19, suggesting a role in maternal recognition and initiation of implantation. This transcriptome analysis of the bovine conceptus will provide a blueprint of the dynamic changes in gene expression occurring during maternal recognition and implantation and will complement existing knowledge of the temporal changes in the endometrial transcriptome, thus facilitating a better understanding of conceptus-maternal cross talk during the peri-implantation period of pregnancy. mRNA-seq study of bovine conceptuses at 5 stages of development (days 7, 10, 13, 16 and 19) post fertilization.

2014-04-04 | E-GEOD-56513 | biostudies-arrayexpress

RNA-Sequencing based analysis of bovine endometrium during the maternal recognition of pregnancy

Project description:RNA-Sequencing based analysis of bovine endometrium during the maternal recognition of pregnancy

| PRJNA807310 | ENA

RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation

Project description:Successful establishment and maintenance of pregnancy can be attained only through optimum conceptus-maternal cross talk. Despite significant progress in our understanding of the temporal changes in the transcriptome of the uterine endometrium, we have only a rudimentary knowledge of the genes and pathways governing growth and development of the bovine conceptus. In particular, very little information exists for the posthatchingembryo and elongating conceptus. This period of development is arguably the most important, as approximately 40% of all embryonic loss occurs between Days 8 and 17 of pregnancy in cattle. Here, we describe the global transcriptome profile of the bovine conceptus at five key stages of its pre- and peri-implantation growth (Days 7, 10, 13, 16, and 19) using state-of-the-art RNA sequencing techniques. More than 287 million reads were generated at the five stages, and more than 22 700 unique transcripts were detected. Analysis of variance followed by self-organizing maps identified differentially regulated (P < 0.05) genes organized in nine gene clusters forming a sequential transcript dynamics across these developmental stages. Of particular interest, genes in clusters 3 (n = 236) and 6 (n = 1409) were significantly up-regulated on Days 16 and 19, suggesting a role in maternal recognition and initiation of implantation. This transcriptome analysis of the bovine conceptus will provide a blueprint of the dynamic changes in gene expression occurring during maternal recognition and implantation and will complement existing knowledge of the temporal changes in the endometrial transcriptome, thus facilitating a better understanding of conceptus-maternal cross talk during the peri-implantation period of pregnancy.

2014-04-04 | GSE56513 | GEO

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