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Genomic changes in response to different doses of early life stress in the developing hippocampus

ABSTRACT: Genomic changes in response to different doses of early life stress in the developing hippocampus

PROVIDER: PRJNA596505 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10735527_1.fastq.gz	Fastqsanger.gz
	SRR10735527_2.fastq.gz	Fastqsanger.gz
	SRR10735528_1.fastq.gz	Fastqsanger.gz
	SRR10735528_2.fastq.gz	Fastqsanger.gz
	SRR10735529_1.fastq.gz	Fastqsanger.gz

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Project description:The goal of this project was to identify genes whose expression is modified by age in microglia isolated from the hippocampus of 14 and 28-day old control mice (i.e. normally developing mice). To accomplish this we used two independent cohorts of control mice and identified a list of 76 genes that were significantly regulated by age (p< 0.05) in both cohorts. Data for cohort 1 were extracted from gene expression of P14 and P28 control mice available in the BDS-P14-male series (GSE81036) and BDS-P28-male series (GSE81037). Data for cohort 2 are available in this series. These data are summarized also in Table S3 in Delpech J.C. et al. Early life stress perturbs the maturation of microglial cells in the developing hippocampus, Brain, Behavior and Immunity, 2016 (in preparation).

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