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Transcriptomic analysis of fungus Penicillium oxalicum 114, laeA deletion strains and histone H2B point mutant strains

ABSTRACT: Transcriptomic analysis of fungus Penicillium oxalicum 114, laeA deletion strains and histone H2B point mutant strains

PROVIDER: PRJNA598119 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10803500.fastq.gz	Fastqsanger.gz
	SRR10803501.fastq.gz	Fastqsanger.gz
	SRR10803502.fastq.gz	Fastqsanger.gz
	SRR10803503.fastq.gz	Fastqsanger.gz
	SRR10803504.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of fungus Penicillium oxalicum 114, laeA deletion strains and histone H2B point mutant strains

Project description:RNA-seq was used to compare the responses of laeA deletion strain and histone H2B point mutant strains . The wild-type strain were also studied.

2022-12-30 | GSE142715 | GEO

Transcriptomic analysis of fungus Penicillium oxalicum and its laeA deletion strains in 24h and 60h

Project description:The goals of this study are to compare differential gene expressions for Penicillium oxalicum wild type strain (WT), and laeA knockout strain (ΔlaeA) in different development phase. The deletion of laeA downregulated genes involved in oxidation- reduction process, alkaloid metabolic process, and transmembrane transport. We find the expression levels of seven secondary metabolism gene clusters (totally 28 clusters) were silenced inΔlaeA. This study provides the information that laeA function are required in conidiation and hydrolase activity of P. oxalicum. Examination of differential gene expressions by digital gene expression tag profiling in Penicillium oxalicum wild type strain and laeA knockout mutant strains in 24h and 60h in modified Czapek culture medium with 2% glucose as carbon resource. qRT–PCR validation was performed using SYBR Green assays.

2015-07-27 | E-GEOD-71287 | biostudies-arrayexpress

Transcriptomic analysis of fungus Penicillium oxalicum and its laeA and creA deletion strains

Project description:The goals of this study are to compare differential gene expressions for Penicillium oxalicum wild type strain (WT), laeA knockout strain (M-NM-^TlaeA), creA knockout strain (M-NM-^TcreA), and double genes knockout strain (M-NM-^TlaeAM-NM-^TcreA). The deletion of laeA downregulated genes involved in oxidation- reduction process, alkaloid metabolic process, and transmembrane transport. We find the expression levels of seven secondary metabolism gene clusters (totally 28 clusters) were silenced inM-NM-^TlaeA. The deletion of creA upregulated genes involved in hydrolase activity, acting on glycosyl bonds. Many genes involved in conidiation were drastically regulated inM-NM-^TlaeAM-NM-^TcreA. This study provides the information that combined laeA and creA function are required in conidiation and hydrolase activity of P. oxalicum. Examination of differential gene expressions by digital gene expression tag profiling in Penicillium oxalicum wild type strain and three mutant strains (laeA knockout strain, creA knockout strain and double genes knockout strain). qRTM-bM-^@M-^SPCR validation was performed using SYBR Green assays.

2014-11-19 | E-GEOD-63408 | biostudies-arrayexpress

Transcriptomic analysis of fungus Penicillium oxalicum and its laeA deletion strains in 24h and 60h

2015-07-27 | GSE71287 | GEO

Transcriptomic analysis of fungus Penicillium oxalicum and its laeA and creA deletion strains

Project description:The goals of this study are to compare differential gene expressions for Penicillium oxalicum wild type strain (WT), laeA knockout strain (ΔlaeA), creA knockout strain (ΔcreA), and double genes knockout strain (ΔlaeAΔcreA). The deletion of laeA downregulated genes involved in oxidation- reduction process, alkaloid metabolic process, and transmembrane transport. We find the expression levels of seven secondary metabolism gene clusters (totally 28 clusters) were silenced inΔlaeA. The deletion of creA upregulated genes involved in hydrolase activity, acting on glycosyl bonds. Many genes involved in conidiation were drastically regulated inΔlaeAΔcreA. This study provides the information that combined laeA and creA function are required in conidiation and hydrolase activity of P. oxalicum.

2014-11-19 | GSE63408 | GEO

Transcriptomic analysis of fungus Penicillium oxalicum and its laeA, clrB and rcoA deletion strains

Project description:The goals of this study are to compare differential gene expressions for Penicillium oxalicum wild type strain (WT), laeA knockout strain (ΔlaeA), rcoA knockout strain (ΔrcoA), and clrB knockout strain (ΔclrB). The deletion of laeA downregulated genes involved in oxidation- reduction process, alkaloid metabolic process, and transmembrane transport. We find the expression levels of seven secondary metabolism gene clusters (totally 28 clusters) were silenced inΔlaeA. The deletion of clrB downregulated genes involved in hydrolase activity, acting on glycosyl bonds. Many genes involved in conidiation were drastically regulated in ΔrcoA. This study provides the information that combined laeA, clrB and rcoA function are required in conidiation and hydrolase activity of P. oxalicum.

2021-03-22 | GSE112203 | GEO

methylation sites of Histone H2B catalyzed by LaeA

Project description:In Penicillium oxalicum, histone H2B (PDE_01489) was one of the interacting proteins with the methyltransferase LaeA. It suggests that histone H2B may be a direct target of LaeA/Lae1. To verify whether histone H2B is one of the LaeA targets, an in vitro catalytic experiment was performed using Homo sapiens recombinant histone H2B (HsH2B, expressed in Escherichia coli, without histone modification), SAM as substrates, and LaeA. The products were analyzed by LC-MS/MS for histone modifications. Results showed that the mono and di-methylation of lysine 108 and the mono-methylation of lysine 116 were detected.

2021-07-08 | PXD027171 |

Penicillium oxalicum 114-2

Project description:Penicillium oxalicum 114-2 Genome sequencing and assembly

| PRJNA60877 | ENA

Penicillium oxalicum 114-2

Project description:Penicillium oxalicum 114-2 Transcriptome or Gene expression

| PRJNA223338 | ENA

Transcriptomic analysis of LaeA and LaeB deletion strains in fungus Beauveria bassiana

Project description:Transcriptomic analysis of LaeA-deletion and overexpression LaeB in LaeA deletion strains in fungus Beauveria bassiana

2013-12-05 | GSE52995 | GEO