Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide maps of chromatin state and gene expression in mouse liver.

ABSTRACT: Genome-wide maps of chromatin state and gene expression in mouse liver.

PROVIDER: PRJNA598444 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10811474.fastq.gz	Fastqsanger.gz
	SRR10811475.fastq.gz	Fastqsanger.gz
	SRR10811476.fastq.gz	Fastqsanger.gz
	SRR10811477.fastq.gz	Fastqsanger.gz
	SRR10811478.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Genome-wide maps of chromatin state in liver cells.

Project description:Genome-wide maps of chromatin state in liver cells.

| PRJNA526252 | ENA

Genome-wide maps of chromatin state in refed mouse liver.

Project description:Genome-wide maps of chromatin state in refed mouse liver.

| PRJNA541769 | ENA

Genome-wide maps of chromatin state in liver.

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse liver. We find that lysine 4 and lysine 27 trimethylation effectively discriminates genes that are expressed, poised for expression, or stably repressed, and therefore reflect cell state and lineage potential. Lysine 36 trimethylation marks primary coding and non-coding transcripts, facilitating gene annotation. Trimethylation of lysine 9 and lysine 20 is detected at satellite, telomeric and active long-terminal repeats, and can spread into proximal unique sequences. Lysine 4 and lysine 9 trimethylation marks imprinting control regions. Finally, we show that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms. This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations.

2021-07-27 | GSE151502 | GEO

Genome-wide maps of chromatin state in mTECs

Project description:Genome-wide maps of chromatin state in mTECs

| PRJNA433526 | ENA

Genome-wide maps of chromatin state in liver cells.

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse liver cells. We find that lysine 4 trimethylation effectively discriminates genes that are expressed, poised for expression, or stably repressed, and therefore reflect cell state and lineage potential. Lysine 9 and 27 trimethylation marks primary coding and non-coding transcripts, have no differents in gene annotation. Trimethylation of lysine 4 is detected has different expresssion at mir124 site front of lnc-RNA(10835)Far. Finally, we show that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms. This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations.

2020-03-08 | GSE128073 | GEO

Genome-wide maps of chromatin state in renin cells

Project description:Genome-wide maps of chromatin state in renin cells

| PRJNA483023 | ENA

Genome-wide maps of chromatin state in HepG2 cells.

Project description:Genome-wide maps of chromatin state in HepG2 cells.

| PRJNA551287 | ENA

Genome-wide maps of chromatin state in saccharomyces cerevisiae

Project description:Genome-wide maps of chromatin state in saccharomyces cerevisiae

| PRJNA612040 | ENA

Genome-wide maps of chromatin state in HeLa cells.

Project description:Genome-wide maps of chromatin state in HeLa cells.