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Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse WGBS]

ABSTRACT: Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse WGBS]

PROVIDER: PRJNA598572 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10815031_1.fastq.gz	Fastqsanger.gz
	SRR10815031_2.fastq.gz	Fastqsanger.gz
	SRR10815032_1.fastq.gz	Fastqsanger.gz
	SRR10815032_2.fastq.gz	Fastqsanger.gz
	SRR10815033_1.fastq.gz	Fastqsanger.gz

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Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse WGBS]

Project description:DNA methylation is a universal epigenetic mechanism involved in regulation of gene expression and genome stability. The DNA maintenance methylase DNMT1 ensures that DNA methylation patterns are faithfully transmitted to daughter cells during cell division. Because DNMT1 is essential for cell viability, little is known about its tissue-specific function. To overcome this impediment, forward genetic screens were conducted in medaka and zebrafish to identify viable dnmt1 alleles. The recovered recessive missense mutations lead to distorted structures of the catalytic pocket and reduced enzymatic activities, resulting in hypomethylation of genomic DNA that specifically impairs lymphoid development. The insights gleaned from fish dnmt1 alleles enabled the structure-guided generation of a hypomorphic variant of mouse Dnmt1, which also causes cell-autonomous defects of lymphoid development. The similar phenotypes observed in three distinct species suggest that the unique sensitivity of lymphocytes to perturbations of DNA methylation patterns is an evolutionarily conserved feature of all vertebrates.

2020-07-07 | GSE142834 | GEO

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1

Project description:Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1

| PRJNA385812 | ENA

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 (Medaka)

2020-07-07 | GSE98646 | GEO

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 (Zebrafish)

2020-07-07 | GSE141114 | GEO

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse RNA-seq]

2020-07-07 | GSE142223 | GEO

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 (Zebrafish)

Project description:Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 (Zebrafish)

| PRJNA592151 | ENA

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse RNA-seq]

Project description:Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1 [Mouse RNA-seq]

| PRJNA596243 | ENA

Structural basis of epigenetic protection of mouse lymphoid progenitor cells by Dnmt1

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-07 | GSE98648 | GEO

Mouse preimplantation imprinting [WGBS]

Project description:Mouse preimplantation imprinting [WGBS]

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The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells

Project description:We generated WGBS datasets from mESCs treated with the novel drug GSK-3484862 attained from two different commercial sources or the conventional DNMT1 inhitibitor 5-azacytidine. To assess efficacy, datasets were generated from mESCs treated with GSK-3484862 at two concentrations and after treatment for 6 days and 14 days each. Additionally, for comparison purposes, we generated WGBS datasets from Dnmt1/3a/3b deficient mESCs which have very low levels of DNA methylation and WT mESCs treated with DMSO which retain high levels of DNA methylation.

2021-12-14 | GSE184116 | GEO

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