Mnx1 fine tunes neuronal gene expression in motor neurons
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA599127 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR10832100.fastq.gz | Fastqsanger.gz | |||
| SRR10832101.fastq.gz | Fastqsanger.gz | |||
| SRR10832102.fastq.gz | Fastqsanger.gz | |||
| SRR10832103.fastq.gz | Fastqsanger.gz | |||
| SRR10832104.fastq.gz | Fastqsanger.gz |
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Project description:The leukemic cell line GDM-1 was established from a patient with acute myelomonoblastic leukemia [4]. GDM-1 cells carry a reciprocal translocation t(6;7)(q23;q36) juxtaposing the transcription factor (TF) gene motor neuron and pancreas homeobox 1 (MNX1, also designated HLXB9 or HB9) on chromosome 7 (chr7) to the locus of the transcriptional activator MYB on chr6. The translocation does not result in a fusion transcript but leads to aberrant activation of MNX1, suspected to be due to altered topologically associating domains, nuclear positioning or ectopic mechanisms. GDM-1 represents the only AML cell line overexpressing MNX1. Here we demonstrate that the interaction between the MNX1 promoter with a ‘hijacked’ enhancer from the MYB/AHI1 locus leads to ectopic activation of MNX1.
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