Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ATAC-seq]

ABSTRACT: An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ATAC-seq]

PROVIDER: PRJNA599439 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10847731.fastq.gz	Fastqsanger.gz
	SRR10847732.fastq.gz	Fastqsanger.gz
	SRR10847733.fastq.gz	Fastqsanger.gz
	SRR10847734.fastq.gz	Fastqsanger.gz
	SRR10847735.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 45

Similar Datasets

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

Project description:An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

| PRJNA599438 | ENA

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [histones]

Project description:An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [histones]

| PRJNA599427 | ENA

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [RNA-seq]

Project description:An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [RNA-seq]

| PRJNA599425 | ENA

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ChIP-seq]

Project description:An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ChIP-seq]

| PRJNA599432 | ENA

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ATAC-seq]

Project description:Thousands of epigenomic datasets have been generated in the past decade, but it is difficult for researchers to effectively utilize all the data relevant to their projects. Systematic integrative analysis can help meet this need, and the VISION project was established for ValIdated Systematic IntegratiON of epigenomic data in hematopoiesis. Here, we systematically integrated extensive data recording epigenetic features and transcriptomes from many sources, including individual laboratories and consortia, to produce a comprehensive view of the regulatory landscape of differentiating hematopoietic cell types in mouse. By employing IDEAS as our Integrative and Discriminative Epigenome Annotation System, we identified and assigned epigenetic states simultaneously along chromosomes and across cell types, precisely and comprehensively. Combining nuclease accessibility and epigenetic states produced a set of over 200,000 candidate cis-regulatory elements (cCREs) that efficiently capture enhancers and promoters. The transitions in epigenetic states of these cCREs across cell types provided insights into mechanisms of regulation, including decreases in numbers of active cCREs during differentiation of most lineages, transitions from poised to active or inactive states, and shifts in nuclease accessibility of CTCF-bound elements. Regression modeling of epigenetic states at cCREs and gene expression produced a versatile resource to improve selection of cCREs potentially regulating target genes. These resources are available from our VISION website (usevision.org) to aid research in genomics and hematopoiesis.

2020-01-09 | GSE143270 | GEO

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [histones]

2020-01-09 | GSE143265 | GEO

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [ChIP-seq]

2020-01-09 | GSE143266 | GEO

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis [RNA-seq]

2020-01-09 | GSE143261 | GEO

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis.

Project description:Thousands of epigenomic data sets have been generated in the past decade, but it is difficult for researchers to effectively use all the data relevant to their projects. Systematic integrative analysis can help meet this need, and the VISION project was established for validated systematic integration of epigenomic data in hematopoiesis. Here, we systematically integrated extensive data recording epigenetic features and transcriptomes from many sources, including individual laboratories and consortia, to produce a comprehensive view of the regulatory landscape of differentiating hematopoietic cell types in mouse. By using IDEAS as our integrative and discriminative epigenome annotation system, we identified and assigned epigenetic states simultaneously along chromosomes and across cell types, precisely and comprehensively. Combining nuclease accessibility and epigenetic states produced a set of more than 200,000 candidate cis-regulatory elements (cCREs) that efficiently capture enhancers and promoters. The transitions in epigenetic states of these cCREs across cell types provided insights into mechanisms of regulation, including decreases in numbers of active cCREs during differentiation of most lineages, transitions from poised to active or inactive states, and shifts in nuclease accessibility of CTCF-bound elements. Regression modeling of epigenetic states at cCREs and gene expression produced a versatile resource to improve selection of cCREs potentially regulating target genes. These resources are available from our VISION website to aid research in genomics and hematopoiesis.

| S-EPMC7111515 | biostudies-literature

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-08 | GSE143271 | GEO