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Loss Of Neural Stem Cell O-Glcnacylation Regulates An Age-Related Fate Switch In The Mature Hippocampus

ABSTRACT: Loss Of Neural Stem Cell O-Glcnacylation Regulates An Age-Related Fate Switch In The Mature Hippocampus

PROVIDER: PRJNA600260 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10859204_1.fastq.gz	Fastqsanger.gz
	SRR10859204_2.fastq.gz	Fastqsanger.gz
	SRR10859205_1.fastq.gz	Fastqsanger.gz
	SRR10859205_2.fastq.gz	Fastqsanger.gz
	SRR10859206_1.fastq.gz	Fastqsanger.gz

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Loss Of Neural Stem Cell O-Glcnacylation Regulates An Age-Related Fate Switch In The Mature Hippocampus

Project description:To gain mechanistic insight into the role of O-GlcNAc in adult hippocampal neural stem cells (NSCs), we treated primary NSCs with a pharmacological inhibitor of Ogt or a lentivirus encoding an shRNA construct targeting Ogt. We determined that loss of O-GlcNAc in NSCs impairs proliferation and activates programs associated with glial differentiation.

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LOSS OF NEURAL STEM CELL O-GLCNACYLATION REGULATES AN AGE-RELATED FATE SWITCH IN THE MATURE HIPPOCAMPUS

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