Project description:Effects of food colorants in C. elegans gene expression is studied. Microarrays were used to analyze the global programme of gene expression underlying the lifespan change and identified distinct classes of up/down-regulated genes in animals treated with food colorants.
Project description:When C. elegans larvae hatch in the absence of food they persist in a stress resistant, developmentally arrested state (L1 arrest). We characterized mRNA expression genome-wide in a pair of bifurcating time series starting in the late embryo and proceeding through the hatch in the presence and absence of food (E. coli). We used Affymetrix C. elegans expression arrays to measure gene expression in 18 total timepoint/conditions in three biological replicates. Keywords: time course; plus/minus food
Project description:Effects of baicalein in C. elegans gene expression is studied, as our results indicate a lifespan extension effect produced by this molecule. Microarrays were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated genes in animals treated with baicalein.
Project description:Effects of betalains in C. elegans gene expression is studied, as our previous results showed a lifespan extension effect produced by theses molecules Microarrays were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated genes in animals treated with betalains.
Project description:Gene expression in N2 worms treated with 500 μM or 0 μM ferulic acid, at days 5. Effects of ferulic acid in C. elegans gene expression is studied, as our results indicate a lifespan extension effect produced by this molecule. RNA-seq were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated genes in animals treated with ferulic acid.
Project description:Effects of tryptophan derived-betaxanthins in C. elegans Jk1466 strain gene expression is studied. Microarrays were used to detail the global programme of gene expression underlying the lifespan extension and identified distinct classes of up/down-regulated genes in animal treated with tryptophan-derived betaxanthins