Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of LPS on gene expression and the role of Lamin-A

ABSTRACT: Effect of LPS on gene expression and the role of Lamin-A

PROVIDER: PRJNA602735 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10953968.fastq.gz	Fastqsanger.gz
	SRR10953969.fastq.gz	Fastqsanger.gz
	SRR10953970.fastq.gz	Fastqsanger.gz
	SRR10953971.fastq.gz	Fastqsanger.gz
	SRR10953972.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Examination of effect of LPS on chromatin accessibility and the role of Lamin-A [ATAC-Seq]

Project description:We report here the ATAC-Seq data for Control, Control LPS treated, Lamin-A-KO and Lamin-A-KO LPS treated

2023-12-31 | GSE147827 | GEO

Effect of LPS on gene expression and the role of Lamin-A

Project description:We report here the RNA-Seq data for WT_BMDMs_Untreated, WT_BMDMs_LPS Treated, LAMIN-A-KO_BMDMs_Untreated and Lamin-A--KO_BMDMs_LPS Treated

2022-12-31 | GSE144094 | GEO

Examination of effect of LPS on chromatin accessibility and the role of Lamin-A [ATAC-Seq]

Project description:Examination of effect of LPS on chromatin accessibility and the role of Lamin-A [ATAC-Seq]

| PRJNA622068 | ENA

Role of Lamin A/C on dendritic cell function in antiviral immunity

Project description:Dendritic cells (DCs) play a crucial role in orchestrating immune responses, particularly in promoting IFNγ-producing-CD8 cytotoxic T lymphocytes (CTLs) and IFNγ-producing -CD4 T helper 1 (Th1) cells, which are essential for defending against viral infections. Additionally, the nuclear envelope protein lamin A/C has been implicated in T cell immunity. Nevertheless, the intricate interplay between innate and adaptive immunity in response to viral infections, particularly the role of lamin A/C in DC functions within this context, remains poorly understood. In this study, we demonstrate that mice lacking lamin A/C in myeloid LysM promoter-expressing cells exhibit a reduced capacity to induce Th1 and CD8 CTL responses, leading to impaired clearance of acute primary Vaccinia virus (VACV) infection. Remarkably, in vitro-generated granulocyte macrophage colony-stimulating factor bone marrow-derived DCs (GM-CSF BMDCs) show high levels of lamin A/C. Lamin A/C absence on GM-CSF BMDCs does not affect the expression of costimulatory molecules on the cell membrane but it reduces the cellular ability to form immunological synapses with naïve CD4 T cells. Lamin A/C deletion induces alterations in NFκB nuclear localization, thereby influencing NFκB-dependent transcription. Furthermore, lamin A/C ablation modifies the epigenetic signature of BMDCs, predisposing these cells to mount a less effective antiviral response upon TLR stimulation. This study highlights the critical role of DCs in interacting with CD4 T cells during antiviral responses and elucidates the molecular mechanisms through which lamin A/C modulates DC function via epigenetic and transcriptional regulation.

2024-09-18 | GSE269613 | GEO

Effect of LPS and LPS-binding protein treatment on RAW 264.4 cells

Project description:All samples were gathered from mouse RAW 264.7 cells (macrophages). Control total RNA was extracted from untreated RAW 264.7 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. Test total RNA was extracted from lipopolysaccharide (100ng/ml) and lipopolysaccharide-binding protein (100pM) treated RAW 264.4 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. This SuperSeries is composed of the following subset Series: GSE1099: Effect of LPS and LPS-binding protein treatment for 1 hour on RAW 264.4 cells GSE1100: Effect of LPS and LPS-binding protein treatment for 2 hours on RAW 264.4 cells GSE1101: Effect of LPS and LPS-binding protein treatment for 4 hours on RAW 264.4 cells GSE1102: Effect of LPS and LPS-binding protein treatment for 8 hours on RAW 264.4 cells GSE1103: Effect of LPS and LPS-binding protein treatment for 16 hours on RAW 264.4 cells GSE1104: Effect of LPS and LPS-binding protein treatment for 48 hours on RAW 264.4 cells Refer to individual Series

2004-03-04 | E-GEOD-1098 | biostudies-arrayexpress

Gene Profile of RU486 effect on LPS induced gene expression in CNS.

Project description:The study was designed in order to identify genes differentially expressed when glucocorticoid signaling is blocked by a glucocorticoid-receptor antagonist (RU486 – mifepristone) in the context of brain inflammation induced by bacterial lipopolysaccharide (LPS). LPS is only able to cause murine brain damage in our experimental conditions upon RU486 pre-treatment. Hence, the study may reveal potential candidate genes to mediate neuroprotection or neurotoxicity. Due to the factorial design of the experiment, RU486 main-effect could be dissociated from the effects resultant of RU486/inflammation interaction. In addition, brain dissection was conducted to verify the effects in the brain side ipsilateral or contralateral to the site of intracerebral LPS infusion. Keywords: Brain, CNS, LPS, Glucocorticoid, RU486, Mifrespitone, Innate immune response, Inflammation, Affymetrix, Gene profile, Neuroprotection, Neurodegeneration, Factorial design.

2007-03-22 | GSE6509 | GEO

Role of RUVBL2 in LPS-induced proinflammatory gene expression of RAW264.7 cells

Project description:Role of RUVBL2 in LPS-induced proinflammatory gene expression of RAW264.7 cells

| PRJNA664108 | ENA

Lamin and Lamin B receptor knockout

Project description:influence of lamin B rereceptor knockout and lamin A/C knockout on gene expression in cultured myoblast cells and in striated muscle tissue knockout samples are obtained by mating of heterozygous animals. Homozygous KO and wt animals of one litter are compared. Two boilogical replicates of KO samples are processed in parallel. wt samples are used as controls. One wt sample is processed per KO litter. Where appropriate two wt samples are used as biological replicates.

2013-01-28 | E-GEOD-37076 | biostudies-arrayexpress

Gene expression analysis of Lamin B receptor deficient hematopoietic cells

Project description:Gene expression analysis of Lamin B receptor deficient hematopoietic cells

2011-12-21 | E-TABM-1134 | biostudies-arrayexpress

Effect of LPS-MCM and Hemin-MCM on gene expression of astrocytes

Project description:Effect of LPS-MCM and Hemin-MCM on gene expression of astrocytes

| PRJNA952200 | ENA