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HPV genome expression at invasive cervical carcinomas infected by multiple HPV genotypes

ABSTRACT: HPV genome expression at invasive cervical carcinomas infected by multiple HPV genotypes

PROVIDER: PRJNA603319 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10969800_1.fastq.gz	Fastqsanger.gz
	SRR10969800_2.fastq.gz	Fastqsanger.gz
	SRR10969801_1.fastq.gz	Fastqsanger.gz
	SRR10969801_2.fastq.gz	Fastqsanger.gz
	SRR10969802_1.fastq.gz	Fastqsanger.gz

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HPV genome expression at invasive cervical carcinomas infected by multiple HPV genotypes

Project description:Multiple HPV genotypes infection is frequently detected in HPV+ cervical lesions, however it is not well stablished how is the different viral interaction during the carcinogenic process. Here we carried out a comprehensive study to characterize the multiple HPV genome expression and integration by RNA-Seq analysis in 19 invasive cervical carcinomas with HPV coinfections. Analysis of tumoral DNA by a hybridization kit indicated multi-infection ranging from 2 to 6 different HPV genotypes, without a preferential species coinfection. The expression analysis showed that a single HPV genotype preferentially expressed its genome, might indicating a competition between the infecting virus. Finally, the search for HPV/human chimeric transcripts indicated integration from just one HPV in almost all samples, corroborating the expression findings.

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