Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Accurate chromosome-scale haplotype-resolved assembly of human genomes

PROVIDER: PRJNA604249 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11016318_1.fastq.gz	Fastqsanger.gz
	SRR11016318_2.fastq.gz	Fastqsanger.gz
	SRR11016319_subreads.fastq.gz	Fastqsanger.gz
	SRR11347815_1.fastq.gz	Fastqsanger.gz
	SRR11347815_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Project description:Haplotype-resolved chromosome-scale genomes of the Asian and African Savannah Elephants

| PRJNA1006510 | ENA

Humulus lupulus

Project description:Chromosome scale haplotype resolved genome assembly of hop cv. Apollo

| PRJNA1082089 | ENA

Aegilops_mutica_genome_assembly

Project description:A chromosome-scale haplotype-resolved assembly of Aegilops mutica genome

| PRJEB81109 | ENA

Musa acuminata AAA Group strain:Cavendish Baxijiao

Project description:Chromosome-scale haplotype-resolved assembly of triploid cultivated banana Cavendish

| PRJDB16592 | ENA

Project description:Chromosome-scale, haplotype-resolved genome assembly of a tetraploid potato cultivar

| PRJNA751899 | ENA

Musa acuminata AAAA Group strain:Gros Michel

Project description:Chromosome-scale haplotype-resolved assembly of triploid cultivated banana Gros Michel

| PRJDB16593 | ENA

Solanum tuberosum cultivar:Otava

Project description:Chromosome-scale, haplotype-resolved genome assembly of a tetraploid potato cultivar

| PRJNA726019 | ENA

CRISPR-based targeted haplotype-resolved assembly of a megabase region [EPIC]

Project description:Constructing high-quality haplotype-resolved genome assemblies has substantially improved the ability to detect and characterize genetic variants. A targeted approach providing readily access to the rich information from haplotype-resolved genome assemblies will be appealing to groups of basic researchers and medical scientists focused on specific genomic regions. Here, using the 4.5 megabase, notoriously difficult-to-assemble major histocompatibility complex (MHC) region as an example, we demonstrated an approach to construct haplotype-resolved assembly of the targeted genomic region with the CRISPR-based enrichment. Compared to the results from haplotype-resolved genome assembly, our targeted approach achieved comparable completeness and accuracy with reduced computing complexity, sequencing cost, as well as the amount of starting materials. Moreover, using the targeted assembled personal MHC haplotypes as the reference both improves the quantification accuracy for sequencing data and enables allele-specific functional genomics analyses of the MHC region. Given its highly efficient use of resources, our approach can greatly facilitate population genetic studies of targeted regions, and may pave a new way to elucidate the molecular mechanisms in disease etiology.

2022-11-15 | GSE192501 | GEO

CRISPR-based targeted haplotype-resolved assembly of a megabase region [WGBS]

2022-11-15 | GSE192499 | GEO

Project description:Chromosome-scale and haplotype-resolved genome assembly of the autotetraploid Misgurnus anguillicaudatus

| PRJNA1120624 | ENA