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Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue [P11]

ABSTRACT: Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue [P11]

PROVIDER: PRJNA605145 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11039161.fastq.gz	Fastqsanger.gz
	SRR11039162.fastq.gz	Fastqsanger.gz
	SRR11039163.fastq.gz	Fastqsanger.gz
	SRR11039164.fastq.gz	Fastqsanger.gz
	SRR11039165.fastq.gz	Fastqsanger.gz

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Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue

Project description:Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue

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Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue [P29]

Project description:Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue [P29]

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Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue [P11]

Project description:To analyse gene expression differences between Wildtype and Bbs8 knockout mouse RPE tissues at two different developmental times points.

2021-03-10 | GSE144845 | GEO

Transcriptome profile of Bbs8/TTC8 Knockout mouse RPE Tissue [P29]

Project description:To analyse gene expression differences between Wildtype and Bbs8 knockout mouse RPE tissues at two different developmental times points.

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Expression data from PyMT P11-KO or P11-WT mammary tumours

Project description:S100A10 (p11) is a plasminogen receptor that regulatess cellular plasmin generation by cancer cells. In the current study we used the MMTV-PyMT mouse breast cancer model to investigate the role of p11 in oncogenesis. Genetic deletion of p11 resulted in significantly decreased tumor onset, growth rate and spontaneous pulmonary metastatic burden in the PyMT/p11-KO mice. This phenotype was accompanied by substantial reduction in Ki67 positivity, macrophage infiltration and decreased vascular density in the primary tumors, and appearance of invasive carcinoma and pulmonary metastasis. Surprisingly, immunohistochemical analysis of wild-type MMTV-PyMT mice failed to detect p11 expression in the tumors or metastatic tumor cells and loss of p11 did not decrease plasmin generation in the PyMT tumors and cells. Furthermore, tumor cells expressing p11 displayed dramatically reduced lung metastasis when injected into p11-depleted mice, further strengthening the stromal role of p11. Transcriptome analysis of the p11-depleted tumors showed marked reduction in genes involved in breast cancer development, progression, and inflammation such as AREG, MUC1 and S100A8. The PyMT/p11-KO tumors displayed remarkable increase in inflammatory cytokines such as IL-6, IL-10 and IFN-γ. Gene expression profiling and immunohistochemistry primary breast cancer samples showed that p11 mRNA and protein was significantly higher in tumors compared to normal mammary tissue. The mRNA expression was significantly associated with poor patient prognosis and significantly elevated in high grade, triple negative tumors and tumors with high proliferative index. We used microarray to detail the global programme of gene expression underlying reduced growth/establishment of P11-KO PyMT tumours.

2023-06-01 | GSE151579 | GEO

CRISPR knockout screening data and RNAsequencing in LINE-1(+) RPE cells

Project description:CRISPR knockout screens were performed in RPE cells with or without wildtype p53 function to determine the genetic fitness interactions that occur upon induction of LINE-1 protein expression. We also performed RNAseq analysis in wildtype p53 RPE cells expressing LINE-1 or Luciferase control to determine transcriptomic changes that occur upon LINE-1 expression.

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Effect of POLDIP2 knockout in ARPE-19 cells

Project description:To study the function of AMD-associated gene POLDIP2 in retinal pigment epithelial (RPE) cells, we used CRISPR/Cas to knockout POLDIP2 in the human RPE cell line ARPE19. We then performed RNA-seq to profile the transcriptome of wildtype ARPE19 and POLDIP2 knockout.

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Project description:We report RNA-Seq analysis of the transcriptome of retinas and RPE/choroids from Abca4 knockout, Abca4 L541P;A1038V knockin and control wild type mice in order to better understand changes in gene regulation that could lead to retinal pathology in mice with ABCA4 deficiency/defect. Retinal and RPE/choroidal mRNA profiles of 30-day-old wild type (WT), Abca4-/- and Abca4L541P;A1038V/L541P;A1038V mice were generated by RNA-Seq, using Illumina Hiseq 2500

2015-04-07 | E-GEOD-63772 | biostudies-arrayexpress

mouse retinal pigmented epithelium (RPE)-LC/MS/MS

Project description:In this experiment, we compared the phosphorylated protein profile of Cryba1 cKO (RPE-specific) RPE tissue and that of the age-matched control samples.

2021-09-07 | PXD026777 | Pride

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Project description:Purpose: To identify gene expression changes in cholinergic neurons of the ventral striatum of p11 cKO mice Method: Translating Ribosome Affinity Purification (TRAP) to isolate RNA from ChAT+ cells and, cDNA synthesisi and next generation RNAseq using Illumina Hiseq sequencer. Results: Biostatistical analysis identified 113 genes that were altered by p11. 59 genes were up-regulated and 54 down-regulated.

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