Homeostatic leukotrienes, IL-25, and IL-33 signals on intestinal ILC2 status
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA605441 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR11041273.fastq.gz | Fastqsanger.gz | |||
| SRR11041274.fastq.gz | Fastqsanger.gz | |||
| SRR11041275.fastq.gz | Fastqsanger.gz | |||
| SRR11041276.fastq.gz | Fastqsanger.gz | |||
| SRR11041277.fastq.gz | Fastqsanger.gz |
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Project description:ILC2 cells are a newly described cell type whose biology and contribution to disease are poorly understood. ILC2 cells are activated by allergens, viral infection, and/or epithelial damage via IL-33 and IL-25. ILC2 cells require IL-2, IL-7, IL-25 and IL-33 for their survival and expansion. In mice, ILC2s produce multiple mediators primarily associated with type 2 inflammation (IL-13, IL-5, IL-4, IL-6, IL-9, IL-10, GM-CSF, amphiregulin). ILC2 cells may contribute to the pathology of asthma through multiple mediators that include IL-13-independent pathways. Our goal is to compare transcriptional profiles of IL-33- or IL-25-activated ILC2 cells from blood to characterize these cells and to identify marker(s) that can be utilized to detect them in human tissue.
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