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Sequencing of mRNA in AML cells upon ALKBH5 knockdown

ABSTRACT: Sequencing of mRNA in AML cells upon ALKBH5 knockdown

PROVIDER: PRJNA605450 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11041649.fastq.gz	Fastqsanger.gz
	SRR11041650.fastq.gz	Fastqsanger.gz
	SRR11041651.fastq.gz	Fastqsanger.gz
	SRR11041652.fastq.gz	Fastqsanger.gz
	SRR11041653.fastq.gz	Fastqsanger.gz

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Sequencing of mRNA in AML cells upon ALKBH5 knockdown

Project description:To identify the potential mRNA targets of ALKBH5, we conducted RNA-seq of mRNA samples enriched from AML cells with ALKBH5 knockdown

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Transcriptome analyses of trophoblast upon ALKBH5 knockdown

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Project description:N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as a new mammalian demethylase that oxidatively removes the m6A modification in mRNA in vitro and inside cells. This demethylation activity of ALKBH5 significantly affects mRNA export and RNA metabolism as well as the assembly of mRNA processing factors in nuclear speckles. Alkbh5-deficient male mice are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase-stage spermatocytes. In accordance with this defect, we have identified in mouse testes 1552 differentially expressed genes which cover broad functional categories and include spermatogenesis-related mRNAs involved in the p53 functional interaction network. We show that Alkbh5-deficiency impacts the expression levels of some of these mRNAs, supporting the observed phenotype. The discovery of this new RNA demethylase strongly suggests that the reversible m6A modification plays fundamental and broad functions in mammalian cells. RNA-seq in two cell types

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Project description:To investigate how ALKBH5 modulates RA FLSs functions, we conducted m6A sequencing (MeRIP-seq) of RA FLSs. Consistent with previous studies, in both scramble controls and ALKBH5 knockdown cells, m6A modifications were highly enriched within the GGAC motif. m6A peaks are located mainly in the protein-coding region (CDS) and 3’ untranslated region (3’ UTR) of mRNA transcripts

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2022-07-07 | GSE180207 | GEO

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