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Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (bulkRNA-seq)

ABSTRACT: Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (bulkRNA-seq)

PROVIDER: PRJNA606473 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11077449.fastq.gz	Fastqsanger.gz
	SRR11077450.fastq.gz	Fastqsanger.gz
	SRR11077451.fastq.gz	Fastqsanger.gz
	SRR11077452.fastq.gz	Fastqsanger.gz
	SRR11077453.fastq.gz	Fastqsanger.gz

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Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (bulkRNA-seq)

Project description:Differences in female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. The characterization of the mechanisms that drive differential neutrophil phenotypes between genders has been investigated. This provides new insights that distinct sex difference in neutrophil biology related to responses to type I IFNs, immunometabolism and maturation status that may have prominent functional and pathogenic implications. The transcriptome of neutrophils from healthy adult males and females was characterized using bulk RNASeq. The transcriptome of whole blood leukocytes was elucidated using scRNASeq.

2020-06-29 | GSE145229 | GEO

Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism

Project description:Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism

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Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (scRNA-seq)

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Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (scRNA-seq)

Project description:Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism (scRNA-seq)

| PRJNA606472 | ENA

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism.

Project description:Differences between female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. We previously reported that neutrophils from reproductive-age males are more immature and less activated than their female counterparts. To further characterize the mechanisms that drive differential neutrophil phenotypes, we performed RNA sequencing on circulating neutrophils from healthy adult females and males. Female neutrophils displayed significant up-regulation of type I IFN (IFN)-stimulated genes (ISGs). Single-cell RNA-sequencing analysis indicated that these differences are neutrophil specific, driven by a distinct neutrophil subset and related to maturation status. Neutrophil hyperresponsiveness to type I IFNs promoted enhanced responses to Toll-like receptor agonists. Neutrophils from young adult males had significantly increased mitochondrial metabolism compared to those from females and this was modulated by estradiol. Assessment of ISGs and neutrophil maturation genes in Klinefelter syndrome (47, XXY) males and in prepubescent children supported that differences in neutrophil phenotype between adult male and female neutrophils are hormonally driven and not explained by X chromosome gene dosage. Our results indicate that there are distinct sex differences in neutrophil biology related to responses to type I IFNs, immunometabolism, and maturation status that may have prominent functional and pathogenic implications.

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Sex differences in neutrophil biology modulate response to type I Interferons and immunometabolism

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-06-29 | GSE145231 | GEO

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Functional evaluation of neutrophil of patients at high risk for infection treated with monocyte/ neutrophil apheresis

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