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Rapid remodeling of poised chromatin landscapes and transcription factor repurposing facilitate gene induction in natural killer cells

ABSTRACT: Rapid remodeling of poised chromatin landscapes and transcription factor repurposing facilitate gene induction in natural killer cells

PROVIDER: PRJNA606695 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR11087500.fastq.gz	Fastqsanger.gz
	SRR11087501.fastq.gz	Fastqsanger.gz
	SRR11087502.fastq.gz	Fastqsanger.gz
	SRR11087503.fastq.gz	Fastqsanger.gz

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Rapid remodeling of poised chromatin landscapes and transcription factor repurposing facilitate gene induction in natural killer cells

Project description:Innate immune responses rely on rapid and precise orchestration of gene regulation mediated by accessibility of regulatory regions to key transcription factors. However, the extent to which acute activation alters accessibility and the roles of distinct classes of transcription factors in this process are unsatisfactorily understood. Here, we investigated and integrated epigenomic modifications and transcriptomic changes occurring upon activation of natural killer (NK) cells.

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Poised enhancers regulatory activity is topologically facilitated by polycomb [RNA-seq LHX5]

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