Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-030587)

ABSTRACT: 19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-030587)

PROVIDER: PRJNA606783 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

Project description:Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. In both sets, the lowest age group significantly associated with 19p loss (discovery set: 20%; validation set: 35%) was 6 years. The 19p loss was considered to be a significant marker for overall survival in patients over 6 years of age. Relevant tumor suppressor genes (KEAP1, DNM2, SMARCA4, SLC44A2 and CDKN2D) and microRNAs (miR-181c, miR-27a, and mirR-199a-1) were in 19p loss. Down-regulation of DNM2, SLC44A2 and CDKN2D associated with poor patient outcome and older age. Among the recurrent NB chromosomal aberrations, only 1q gain was enriched in patients older than 6 years and was mutually exclusive respect to 19p loss. Our data demonstrate that 19p loss is a genomic biomarker of NBs diagnosed in older children that can predict clinical outcome.

2020-02-15 | GSE145340 | GEO

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-030587)

2020-02-15 | GSE145339 | GEO

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-014950)

2020-02-15 | GSE145338 | GEO

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 1)

2020-02-15 | GSE145336 | GEO

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 2)

2020-02-15 | GSE145337 | GEO

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

| PRJNA606782 | ENA

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-014950)

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-014950)

| PRJNA606784 | ENA

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

| PRJNA606780 | ENA

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 2)

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 2)

| PRJNA606785 | ENA

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 1)

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-013282, dataset 1)

| PRJNA606786 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data