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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [bulk RNA]

ABSTRACT: Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [bulk RNA]

PROVIDER: PRJNA607214 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11100023_1.fastq.gz	Fastqsanger.gz
	SRR11100023_2.fastq.gz	Fastqsanger.gz
	SRR11100024_1.fastq.gz	Fastqsanger.gz
	SRR11100024_2.fastq.gz	Fastqsanger.gz
	SRR11100025_1.fastq.gz	Fastqsanger.gz

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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

Project description:Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease [bulk RNA]

Project description:Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent hypoxia (IH) and is associated with a host of health complications. Although the lung is the first organ to sense changes in oxygen levels, little is known about the consequences of IH to the lung hypoxia-inducible factor- (HIF)-responsive pathways. We hypothesized that exposure to IH would lead to cell-specific up and downregulation of diverse expression pathways. We identified changes in circadian and immune pathways in lungs from mice exposed to IH. Among all cell types, endothelial cells showed the most prominent transcriptional changes. Upregulated genes in myofibroblast cells were enriched for genes associated with pulmonary hypertension and included targets of several drugs currently used to treat chronic pulmonary diseases. A better understanding of the pathophysiologic mechanisms underlying diseases associated with OSA could improve our therapeutic approaches, directing therapies to the most relevant cells and molecular pathways.

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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease.

Project description:Obstructive sleep apnea (OSA) results from episodes of airway collapse and intermittent hypoxia (IH) and is associated with a host of health complications. Although the lung is the first organ to sense changes in oxygen levels, little is known about the consequences of IH to the lung hypoxia-inducible factor-responsive pathways. We hypothesized that exposure to IH would lead to cell-specific up- and downregulation of diverse expression pathways. We identified changes in circadian and immune pathways in lungs from mice exposed to IH. Among all cell types, endothelial cells showed the most prominent transcriptional changes. Upregulated genes in myofibroblast cells were enriched for genes associated with pulmonary hypertension and included targets of several drugs currently used to treat chronic pulmonary diseases. A better understanding of the pathophysiologic mechanisms underlying diseases associated with OSA could improve our therapeutic approaches, directing therapies to the most relevant cells and molecular pathways.

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Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-18 | GSE145436 | GEO

Intermittent Hypoxia ageing

Project description:Expression data from mice exposed to intermittent hypoxia and mice reared for 12 months. We used microarrays to analyze the transcriptome of hippocampus from mice exposed to intermittent hypoxia or aged mice.

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Project description:2017 Mouse intermittent hypoxia (IH) - Aorta & pulmonary artery Contains LC/MS data for 10-week experiments involving mice raised in environments with normal oxygen, intermittent hypoxia (IH).

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