Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (WES)

ABSTRACT: A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (WES)

PROVIDER: PRJNA607549 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11113550_1.fastq.gz	Fastqsanger.gz
	SRR11113550_2.fastq.gz	Fastqsanger.gz
	SRR11113551_1.fastq.gz	Fastqsanger.gz
	SRR11113551_2.fastq.gz	Fastqsanger.gz
	SRR11113552_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (WES)

Project description:Glioblastomas are the most lethal tumors affecting the central nervous system in adults. Simple and inexpensive syngeneic in vivo models that closely mirror human glioblastoma, including interactions between tumor and immune cells, are urgently needed for deciphering glioma biology and developing more effective treatments. Here, we generated mouse glioblastoma cell lines by repeated in-vivo passaging of neural stem cells and tumor tissue of a neural stem cell-specific Pten/p53 double-knockout genetic mouse model. Transcriptome and genome analyses of the cell lines revealed molecular heterogeneity comparable to that observed in human glioblastoma. Upon orthotopic transplantation into syngeneic hosts they formed high-grade gliomas that faithfully recapitulated the histopathological characteristics, invasiveness and infiltration by myeloid cells characteristic of human glioblastoma. These features make our cell lines unique and useful tools to study multiple aspects of glioma pathomechanism and test immunotherapies in syngeneic preclinical models.

2021-01-27 | GSE145558 | GEO

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies

Project description:A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies

| PRJNA607546 | ENA

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (RNA-Seq)

2021-01-27 | GSE145557 | GEO

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (RNA-Seq)

Project description:A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies (RNA-Seq)

| PRJNA607547 | ENA

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-01-27 | GSE145559 | GEO

The LL-100 panel: 100 DSMZ cell lines for blood cancer studies; WES

Project description:For many years, immortalized cell lines have been used as model systems for cancer research. Cell line panels were established for basic research and drug development, but did not cover the full spectrum of leukemia and lymphoma. Therefore, we now developed a novel panel (LL-100), 100 cell lines covering 22 entities of human leukemia and lymphoma including T-cell, B-cell and myeloid malignancies. Importantly, all cell lines are unequivocally authenticated and assigned to the correct tissue. Cell line samples were proven to be free of mycoplasma and virus contamination. Whole exome sequencing (WES) and RNA sequencing (RNA-seq) of the hundred authenticated leukemia-lymphoma cell lines were conducted with a uniform methodology to complement existing data on these publicly available cell lines. This part captures WES. This data set will be useful for understanding the function of oncogenes and tumor suppressor genes and to develop targeted therapies.

2019-05-28 | E-MTAB-7722 | biostudies-arrayexpress

Long-term anti-tumor effects following both conventional radiotherapy and FLASH in fully immunocompetent animals with glioblastoma

Project description:Comparing high grade glioma grown intracranially versus subcutaneously in fully immunocompetent rats

2023-12-31 | E-MTAB-11674 | biostudies-arrayexpress

The IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma (MM) [WES]

Project description:The IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma (MM) [WES]

| PRJNA911731 | ENA

Preclinical development of brain permeable ERβ agonist for the treatment of glioblastoma

Project description:Preclinical development of brain permeable ERβ agonist for the treatment of glioblastoma

| PRJNA941346 | ENA

Characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development

Project description:We have generated a collection of patient-derived xenograft (PDX) tumor models and characterized them at the molecular level to facilitate precision oncology. Surgically resected HCC specimens were subcutaneously implanted in immunodeficient mice. Resulting xenografts were serially implanted to establish transplantable PDX models, which were sequentially subject to whole exome sequencing (WES), gene expression array, genome-wide human single nucleotide polymorphism (SNP) array 6.0, and serum a–fetoprotein (AFP) detection assay. The feasibility as a preclinical model was validated by efficacy studies using a standard-of-care (SOC) and a targeted agent, respectively.

2014-03-13 | E-GEOD-55828 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data