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ABSTRACT: Different stimulation responses of interferon alfa and lambda in Porcine Intestinal Epithelia Cells

PROVIDER: PRJNA607694 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11119408_1.fastq.gz	Fastqsanger.gz
	SRR11119408_2.fastq.gz	Fastqsanger.gz
	SRR11119409_1.fastq.gz	Fastqsanger.gz
	SRR11119409_2.fastq.gz	Fastqsanger.gz
	SRR11119410_1.fastq.gz	Fastqsanger.gz

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Project description:This experiment investigates the transcriptional effect of Interferon Alpha or Interferon Lambda upon Induced Hepatocyte-Like Cells (iHLCs). Peginterferon lambda-1a (Lambda) is a type III interferon that acts through a unique receptor complex expressed primarily on hepatocytes. In Phase 2b clinical studies, a combined regimen of Lambda with ribavirin (RBV) was associated with more rapid declines in viral load compared to a peginterferon alfa (PEGASYS; alfa) plus RBV regimen. This correlated with improved virologic response rates at Weeks 4 and 12 of treatment. To gain insight into the potential molecular mechanisms of these early robust responses with Lambda, we investigated the effects of alfa and Lambda on transcription in iHLCs obtained from Cellular Dynamics.. These samples are a subset of a larger experiment to be published at a later date.

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