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Knockout of EZH2 inhibits the tumorigenicity of human ovarian cancers cells SKOV3 by targeting steroid biosynthesis

ABSTRACT: knockout of EZH2 inhibits the tumorigenicity of human ovarian cancers cells SKOV3 by targeting steroid biosynthesis

PROVIDER: PRJNA607957 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11139126_1.fastq.gz	Fastqsanger.gz
	SRR11139126_2.fastq.gz	Fastqsanger.gz
	SRR11139127_1.fastq.gz	Fastqsanger.gz
	SRR11139127_2.fastq.gz	Fastqsanger.gz
	SRR11139128_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

knockout of EZH2 inhibits the tumorigenicity of human ovarian cancers cells SKOV3 by targeting steroid biosynthesis

Project description:Ovarian cancer has the highest mortality in gynecologic cancers and most patients are diagnosed in advanced stages. EZH2 has been a major tumor markers and effective therapeutic targets for ovarian cancer, which molecular mechanism remain unclear. The present study was investigated the biological effects on EZH2 knock-out SKOV3 cells in vitro and in vivo experiment, and explore the molecular mechanism by integrated analysis of mRNA-seq and CHIP-seq.  CRISPR/Cas9 system was used to establish the knock-out EZH2 SKOV3 cells. Protein expression was detected by Western blot. The effect of EZH2 in ovarian cancer was detected by MTT assay, wound scratch assay and Transwell assay, apoptosis assay in vitro and xenograft model in vivo. mRNA-seq and CHIP-seq was used to explore the molecular mechanism of biological function of EZH2.

2020-02-22 | GSE145692 | GEO

EZH2 and H3K27ac ChIPseq of SKOV3(AA) and SKOV3(CC)

Project description:EZH2 and H3K27ac ChIPseq of SKOV3(AA) and SKOV3(CC)

| PRJNA771867 | ENA

Gene expression change in Skov3 after EZH2 knockdown

2011-12-12 | GSE31433 | GEO

Gene expression change in Skov3 after EZH2 knockdown

Project description:To identify genes whose expression was suppressed by EZH2, we performed gene expression microarray analysis in control and EZH2 knockdown human SKOV3 EOC cells. Two individual short hairpin RNAs to the human EZH2 gene (shEZH2) were used to limit potential off-target effects. Two individual short hairpin RNAs to the human EZH2 gene (shEZH2) were used to limit potential off-target effects. Three technical replicates per group were used.

2011-12-12 | E-GEOD-31433 | biostudies-arrayexpress

RNAseq of SKOV3(AA) and SKOV3(CC)

Project description:To study the effect of rs1192691 on ovarian cancer cells, we generated SKOV3(CC) from SKOV3(A/A) using CRISPR/Cas9 technology and performed RNA-seq.

2022-01-18 | GSE181884 | GEO

RNAseq of SKOV3(AA) and SKOV3(CC)

Project description:RNAseq of SKOV3(AA) and SKOV3(CC)

| PRJNA753808 | ENA

Next Generation Sequencing of Transcriptomes in SKOV3 and rhCCL20-treated SKOV3 cells

Project description:The goals of this study are to compare the transcriptome differences between SKOV3 and rhCCL20-treated SKOV3 cells and identify the defferential expressed genes regulated by rhCCL20 in SKOV3 cells. We treated SKOV3 cells with 5% trehalose (control group) and rhCCL20 protein dissolved in 5% trehalose (experimental group) in vitro. The cells were collected 24 hours after treatment and used for RNA-sequencing.

2020-11-20 | GSE161799 | GEO

H3K27ac, H3K4me3, H3K27me3 and H3K9me3 ChIPseq of SKOV3(AA) and SKOV3(CC)

Project description:To study the effect of rs1192691 on histone modifications, we performed H3K27ac, H3K4me3, H3K27me3 and H3K9me3 in SKOV3(AA) and SKOV3(CC).

2022-01-18 | GSE182333 | GEO

Gene Expression in Taxol Resistance SKOV3 Cells (I)

Project description:To investigate the differences in gene expression between parental SKOV3 cells and the two taxol-resistant cell lines SKOV3/Tx50 and SKOV3/Tx600.

2015-07-16 | GSE58840 | GEO

Gene Expression in Taxol Resistance SKOV3 Cells (primary)

Project description:To investigate the differences in gene expression between parental SKOV3 cells and the two taxol-resistant cell lines SKOV3/Tx50 and SKOV3/Tx600.

2015-07-16 | GSE60335 | GEO

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