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JunB-dependent expression in colonic and Peyer's patch regulatory T cells

ABSTRACT: JunB-dependent expression in colonic and Peyer's patch regulatory T cells

PROVIDER: PRJNA608684 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11178278.fastq.gz	Fastqsanger.gz
	SRR11178279.fastq.gz	Fastqsanger.gz
	SRR11178280.fastq.gz	Fastqsanger.gz
	SRR11178281.fastq.gz	Fastqsanger.gz
	SRR11178282.fastq.gz	Fastqsanger.gz

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JunB-dependent expression in colonic and Peyer's patch regulatory T cells

Project description:Foxp3-expressing regulatory T (Treg) cells are critical mediators of immunological tolerance to both self and microbial antigens. Tregs activate context-dependent transcriptional programs to adapt effector function to specific tissues; however, the factors controlling tissue-specific gene expression in Tregs remain unclear. Here, we find that the AP-1 transcription factor JunB regulates the intestinal adaptation of Tregs by controlling select gene expression programs in multiple Treg subsets. Treg-specific ablation of JunB results in immune dysregulation characterized by enhanced colonic T helper cell accumulation and cytokine production. However, in contrast to its classical binding-partner BATF, JunB is dispensable for maintenance of effector Tregs as well as most specialized Treg subsets. In the Peyer’s patches, JunB activates a transcriptional program facilitating the maintenance of CD25- Tregs, leading to the complete loss of T follicular regulatory cells in the absence of JunB. This defect is compounded by loss of a separate effector program found in both major colonic Treg subsets that includes the cytolytic effector molecule granzyme B. Therefore, JunB is an essential regulator of intestinal Treg effector function through pleiotropic effects on gene expression.

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