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Total RNA Sequencing in microglia isolated from N-AS treated APP/PS1 mice

ABSTRACT: Total RNA Sequencing in microglia isolated from N-AS treated APP/PS1 mice

PROVIDER: PRJNA609355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11207914_1.fastq.gz	Fastqsanger.gz
	SRR11207914_2.fastq.gz	Fastqsanger.gz
	SRR11207915_1.fastq.gz	Fastqsanger.gz
	SRR11207915_2.fastq.gz	Fastqsanger.gz
	SRR11207916_1.fastq.gz	Fastqsanger.gz

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Total RNA Sequencing in microglia isolated from N-AS treated APP/PS1 mice

Project description:To examine the regulation of microglia by N-AS-triggered SPMs, we analyzed the gene expression patterns of microglia derived from WT, APP/PS1, and N-AS-injected APP/PS1 mice using RNAseq. These results indicated that N-AS-triggered SPMs activated an anti-inflammatory, positive immune response, and enhanced the phagocytic abilities of microglia in N-AS-treated APP/PS1 mice, leading to resolution of neuroinflammation and upregulation of phagocytic microglia in this AD animal model.

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