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ABSTRACT: AMF community under fertilization

PROVIDER: PRJNA611471 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR11267150.fastq.gz	Fastqsanger.gz
	SRR11267151.fastq.gz	Fastqsanger.gz
	SRR11267152.fastq.gz	Fastqsanger.gz
	SRR11267153.fastq.gz	Fastqsanger.gz
	SRR11267154.fastq.gz	Fastqsanger.gz

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A study to investigate the effects of long-term organic and integrated fertilization on soil microbial community

Project description:Microbes play key roles in diverse biogeochemical processes including nutrient cycling. However, responses of soil microbial community at the functional gene level to long-term fertilization, especially integrated fertilization (chemical combined with organic fertilization) remain unclear. Here we used microarray-based GeoChip techniques to explore the shifts of soil microbial functional community in a nutrient-poor paddy soil with long-term (21 years).The long-term fertilization experiment site (set up in 1990) was located in Taoyuan agro-ecosystem research station (28°55’N, 111°27’E), Chinese Academy of Sciences, Hunan Province, China, with a double-cropped rice system. fertilization at various regimes.

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Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER

Project description:Traditional surgery plus radiotherapy or chemotherapy, existing targeted therapies failed to significantly improve the survival rate of recurrent endometrial cancer, so suggesting that mechanism of recurrence and progression that modulates in endometrial cancer is clinically important. Here, we show that GPER(G protein-coupled estrogen receptor 1) was binded to AMF, and the complex were translocation form plasma to cytoplasmic. Mechanistic investigations elucidated that interaction of AMF with GPER triggers phosphoinositide-3-kinase (PI3K) signaling activating and accelerating the ability of endometrial cancer cells growth. Furthermore, we found that AMF may contribute to GPER-mediated endometrial cancer progression using animal experiments and human histological experiments which be consistent with the above conclusions. On the basis of these evidences including invivo and invitro, our findings suggest that AMF–GPER interaction might be novel key molecular targets for therapeutic management of patients with endometrial cancer, whose disease were progression and recurrence.

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