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Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing.

ABSTRACT: Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing.

PROVIDER: PRJNA611557 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11271756.fastq.gz	Fastqsanger.gz
	SRR11271757.fastq.gz	Fastqsanger.gz
	SRR11271758.fastq.gz	Fastqsanger.gz
	SRR11271759.fastq.gz	Fastqsanger.gz
	SRR11271760.fastq.gz	Fastqsanger.gz

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Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing.

Project description:1. We used RNA-seq to examine vascular tissue (aorta) transcriptomes from chronic kidney disease rat model (uremic) developing vascular calcifications, compared with controls. Uremic calcified aortas have extensive changes in the transcriptional profile. Among the 10,153 genes with an expression level of >1 reads/kilobase transcript/million mapped reads, 2,663 genes were differentially expressed with 47% upregulated genes and 53% downregulated genes in uremic rats. Significantly deregulated genes were enriched for ontologies related to the extracellular matrix, response to wounding, organic substance, and ossification. The individually affected genes were of relevance to osteogenic transformation, tissue calcification, and Wnt modulation. 2. We demonstrated extensive changes in the transcriptional profile of the uremic calcified aorta, which were consistent with a shift in phenotype from vascular tissue toward an osteochondrocytic transcriptome profile. 3. Moreover, neither the normal vasculature nor calcified uremic vasculature expresses Klotho.

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