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Genome-wide distribution of H1t in mouse spermatogenic cells.

ABSTRACT: Genome-wide distribution of H1t in mouse spermatogenic cells.

PROVIDER: PRJNA611778 | ENA |

REPOSITORIES: ENA

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Genome-wide distribution of H1t in mouse spermatogenic cells.

Project description:We report genome-wide distribution of Linker histone variant H1t in mouse spermatogenic cells. We found that H1t was mainly located at around transcriptional start site of genic area, positively correlated with the gene expression. This study using ChIP-seq analysis provides genomic distribution of H1t in mouse spermatogenic cells.

2023-03-09 | GSE146733 | GEO

Genome-wide distribution of H2A-S40Gc in mouse trophoblast stem cells

Project description:We report genome-wide distribution of O-GlcNAcylated H2A at serine 40 (H2A-S40Gc) in mouse trophoblast stem cells (TSCs). We found that H2A-S40Gc was mainly located at genic area, positively correlated with the gene expression, and varied the localization during their differentiation. This study using ChIP-seq analysis provides genomic distribution of newly O-GlcNAc histone modification.

2016-09-13 | GSE74342 | GEO

Genome-wide distribution of H2AS40Gc in mouse embryonic stem cells.

Project description:We report genome-wide distribution of O-GlcNAcylated H2A at serine 40 (H2AS40Gc) in mouse embryonic stem cells (mESCs, J1 line) cultured in 25 mM glucose (HG-mESCs) or 1 mM glucose (LG-mESCs) condition. We found that H2AS40Gc was mainly located at genic area, positively correlated with the gene expression both in HG- and LG-mESCs. Interestingly, H2AS40Gc localization was overlapped with H2AX, γH2AX and O-GlcNAc transferase (Ogt), and varied by extracellular glucose concentration. This study using ChIP-seq and RNA-seq analysis provides genomic distribution of newly O-GlcNAc histone modification in mESCs.

2020-02-02 | GSE77999 | GEO

Genome-wide distribution of H1foo and somatic H1s in mouse embryonic cells.

Project description:We report genome-wide distribution of linker histone variant H1foo and somatic H1s in mouse embryonic stem cells. We found that H1foo was mainly located at around transcriptional start site of genic area, positively correlated with the gene expression.

2021-06-28 | GSE171829 | GEO

Genome-wide distribution of H1foo and somatic H1s in mouse embryonic cells.

Project description:Genome-wide distribution of H1foo and somatic H1s in mouse embryonic cells.

| PRJNA721086 | ENA

Genome-wide distribution of histones modifications in mouse ESC Rif1+/+ and Rif1-/-

Project description:Genome-wide distribution of histones modifications in mouse ESC Rif1+/+ and Rif1-/-

| PRJEB9864 | ENA

Genome-wide alterations of uracil distribution patterns

Project description:Genome-wide alterations of uracil distribution patterns

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Genome-wide distribution of ZHX3 in human fibroblast cells.

Project description:Genome-wide distribution of ZHX3 in human fibroblast cells.

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Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

2011-03-30 | GSE27613 | GEO

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

Project description:Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-wide profile of 5hmC in mouse embryonic stem (ES) cells. A combined analysis of global 5hmC distribution and gene expression profile in wild-type and Tet1-depleted ES cells revealed suggests that 5hmC is enriched at both gene bodies of actively transcribed genes and extended promoter regions of Polycomb-repressed developmental regulators. Thus, our study reveals the first genome-wide 5hmC distribution in pluripotent stem cells and supports its dual function in regulating gene expression. Genomic DNA extracted from control (Con) or Tet1 knockdown (KD) mouse ES cells was immunoprecipitated with 5-hydroxymethylcytosine (5hmC) antibodies and analyzed by NimbleGen 2.1M mouse whole genome tiling microarrays (a 4-array set covering the entired non-repetitive portion of mouse genome). Whole cell extract (WCE) was used as input controls in IP/input experiments.

2011-03-30 | E-GEOD-27613 | biostudies-arrayexpress

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