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Transcriptome data of miR-483 overexpression in human pulmonary arterial endothelial cells

ABSTRACT: Transcriptome data of miR-483 overexpression in human pulmonary arterial endothelial cells

PROVIDER: PRJNA611932 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11286315_1.fastq.gz	Fastqsanger.gz
	SRR11286315_2.fastq.gz	Fastqsanger.gz
	SRR11286316_1.fastq.gz	Fastqsanger.gz
	SRR11286316_2.fastq.gz	Fastqsanger.gz
	SRR11286317_1.fastq.gz	Fastqsanger.gz

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Transcriptome data of miR-483 overexpression in human pulmonary arterial endothelial cells

Project description:MicroRNA-483 (miR-483) regulate endothelial function through inhibition expression of connective tissue growth factor (CTGF). Endothelial dysfunction is involved in the pathogeneis of pulmonary arterial hypertension (PAH). We investigated the role of miR-483 overexpression on human pulmonary arterial endothelial cells (hPAECs) through comparing the transcriptome file of hPAECs transfected with miR-483 -3p and -5p mimic and with control mimic. Gene ontology analysis showed that several PAH-associated signaling pathways were regulated by miR-483, including transforming growth factor-β signaling, Wnt signaling and inflammatory response, cell adhesion, response to hypoxia, apoptotic processes, oxidative reduction processes and negative regulation of cell migration and proliferation.

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