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Arachidonic acid promotes intestinal regeneration by activating Wnt signaling

ABSTRACT: Arachidonic acid promotes intestinal regeneration by activating Wnt signaling

PROVIDER: PRJNA612250 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11294673_1.fastq.gz	Fastqsanger.gz
	SRR11294673_2.fastq.gz	Fastqsanger.gz
	SRR11294674_1.fastq.gz	Fastqsanger.gz
	SRR11294674_2.fastq.gz	Fastqsanger.gz
	SRR11294675_1.fastq.gz	Fastqsanger.gz

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Arachidonic acid promotes intestinal regeneration by activating Wnt signaling

Project description:We identify arachidonic acid (AA), as a direct proliferation promoter of intestinal epithelial cells, facilitating small intestinal regeneration. In the transcriptomes, it shows that AA treatment upregulated proliferation-related genes including Wnt signaling target genes, while downregulated differentiation-related genes including enterocyte, goblet cell, Paneth cell, enteroendocrine cell, and tuft cell markers. Additionally, AA could also upregulate stem cell-associated genes which have been highly expressed three days after 12Gy IR injury (e.g. Clu, Lamc2, Anxa1, Areg, and Ly6d). The study shows that AA treatment can be considered a potential therapy for irradiation injury repair and tissue regeneration.

2020-07-27 | GSE146871 | GEO

Arachidonic Acid Promotes Intestinal Regeneration by Activating WNT Signaling.

Project description:Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intestinal epithelial cells that facilitates small intestinal regeneration in both three-dimensional cultured organoids and mouse models. As shown in the study, during post-irradiation regeneration, AA positively regulates intestinal epithelial cell proliferation by upregulating the expression of Ascl2 and activating WNT signaling, but negatively regulates intestinal epithelial cell differentiation. AA acts as a delicate regulator that efficiently facilitates epithelial tissue repair by activating radiation-resistant Msi1+ cells rather than Lgr5+ cells, which are extensively considered WNT-activated crypt base stem cells. Additionally, short-term AA treatment maintains optimal intestinal epithelial homeostasis under physiological conditions. As a result, AA treatment can be considered a potential therapy for irradiation injury repair and tissue regeneration.

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Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid [intestinal organoids]

Project description:We evaluated the effects of arachidonic acid (AA) on intestinal stem cell regeneration by RNA-seq and found that AA treatment led to strong upregulation of genes that are associated with stem cell reprogramming across the time points. AA elicits a conserved stem cell regeneration program in mouse intestinal organoids.

2023-03-01 | GSE188213 | GEO

Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid [Organoid]

Project description:Single cell transcriptomic profiling (sc RNA-seq) of arachidonic acid (AA) induced gene expression pogram associated with regeneration in intestinal organoids.

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Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid [In_vivo]

Project description:Single cell transcriptomic profiling (sc RNA-seq) of diatery arachidonic acid (AA) induced gene expression pogram associated with regeneration in intestinal organoids.

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Transcription profiling of human keratinocytes treated with arachidonic acid and platelet activiating factor 16

Project description:Functional role of platelet-activating factor (PAF) induced arachidonic acid release

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Early Age Efferocytosis Directs Macrophage Arachidonic Acid Metabolism for Tissue Regeneration

Project description:Early Age Efferocytosis Directs Macrophage Arachidonic Acid Metabolism for Tissue Regeneration

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Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid

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Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid [intestinal organoids]

Project description:Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid [intestinal organoids]

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HDAC5 regulates arachidonic acid metabolism via cPLA2

Project description:We performed HDAC5 knockdown in pancreatic cancer cells along with RNA sequencing. The result helped us to verify that HDAC5 regulates GATA1 dependent cPLA2 expression and arachidonic acid metabolism.

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