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Artibeus jamaicensis

ABSTRACT: Jamaican fruit-eating bat transcriptome

PROVIDER: PRJNA61227 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR538731.fastq.gz	Fastqsanger.gz
	SRR539297_1.fastq.gz	Fastqsanger.gz
	SRR539297_2.fastq.gz	Fastqsanger.gz

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Artibeus jamaicensis

Project description:Transcriptome Profiling of a Pathogenic Response to a Viral Infection in Jamaican Fruit Bats Artibeus jamaicensis Experimentally Infected With Tacaribe Virus

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Artibeus jamaicensis

Project description:Transcriptome Profiling of a Pathogenic Response to a Viral Infection in Jamaican Fruit Bats Artibeus jamaicensis Experimentally Infected With Tacaribe Virus

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Deciphering bat influenza H18N11 infection dynamics in Jamaican fruit bats on a single cell level

Project description:Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected Jamaican fruit bats with the bat-derived influenza A virus H18N11. Using comparative single-cell RNA sequencing, we generated a single-cell atlas of the Jamaican fruit bat intestine and mesentery, the target organs of infection. Gene expression profiling showed that H18N11 infection resulted in a moderate induction of interferon-stimulated genes and transcriptional activation of immune cells. H18N11 infection was prominent in various leukocytes, including macrophages, B cells, and NK/T cells. Confirming these findings, human leukocytes, particularly macrophages, were also susceptible to H18N11, highlighting the zoonotic potential of this virus. Our study provides insight into the virus-host relationship and thus serves as a fundamental resource for further characterization of bat immunology.

2024-05-06 | GSE243982 | GEO

Artibeus lituratus isolate:mArtLit1

Project description:Artibeus lituratus (great fruit-eating bat) genome, mArtLit1, haplotype 1

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Artibeus intermedius isolate:mArtInt1

Project description:Artibeus intermedius (common fruit-eating bat) genome, mArtInt1, haplotype 2

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Artibeus lituratus isolate:mArtLit1

Project description:Artibeus lituratus (great fruit-eating bat) genome, mArtLit1, haplotype 2

| PRJNA1080657 | ENA

Artibeus intermedius isolate:mArtInt1

Project description:Artibeus intermedius (common fruit-eating bat) genome, mArtInt1, haplotype 1

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Artibeus jamaicensis jamaicensis

Project description:Artibeus jamaicensis jamaicensis Transcriptome or Gene expression

| PRJNA172870 | ENA

Transcriptome Profiling of a Pathogenic Response to a Viral Infection in Jamaican Fruit Bats Artibeus jamaicensis Experimentally Infected With Tacaribe Virus

Project description:Bats are a widespread group of mammals thought to host a variety of viruses and other disease agents. Here we performed RNA-sequencing on Artibeus jamaicensis infected with the New World arenavirus, Tacaribe Virus, to generate an extensive bat transcriptome.

2017-09-07 | GSE75771 | GEO

Transcriptome sequencing and annotation for the Jamaican fruit bat (Artibeus jamaicensis).

Project description:The Jamaican fruit bat (Artibeus jamaicensis) is one of the most common bats in the tropical Americas. It is thought to be a potential reservoir host of Tacaribe virus, an arenavirus closely related to the South American hemorrhagic fever viruses. We performed transcriptome sequencing and annotation from lung, kidney and spleen tissues using 454 and Illumina platforms to develop this species as an animal model. More than 100,000 contigs were assembled, with 25,000 genes that were functionally annotated. Of the remaining unannotated contigs, 80% were found within bat genomes or transcriptomes. Annotated genes are involved in a broad range of activities ranging from cellular metabolism to genome regulation through ncRNAs. Reciprocal BLAST best hits yielded 8,785 sequences that are orthologous to mouse, rat, cattle, horse and human. Species tree analysis of sequences from 2,378 loci was used to achieve 95% bootstrap support for the placement of bat as sister to the clade containing horse, dog, and cattle. Through substitution rate estimation between bat and human, 32 genes were identified with evidence for positive selection. We also identified 466 immune-related genes, which may be useful for studying Tacaribe virus infection of this species. The Jamaican fruit bat transcriptome dataset is a resource that should provide additional candidate markers for studying bat evolution and ecology, and tools for analysis of the host response and pathology of disease.

| S-EPMC3499531 | biostudies-literature

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