Project description:Gastric cancer is the fourth common cancer and second leading cause of cancer related mortality. The survival probability of gastric cancer patients is often less due to the diagnosis at late stage and also due to the heterogenous nature of tumors. Molecular and transcriptome-wide understanding of the dysregulations in gastric tumors from different populations is highly required to delineate the heterogeneity. To delineate the key oncogenic dysregulations in terms of the transcripts, transcription programs and signaling pathways, we performed genome-wide mRNA profiling of human gastric normal and gastric cancer tissues using Affymetrix Human Transcriptome 2.0 arrays.
Project description:In this dataset, we include the expression data obtained from gastric cancer tissues and gastric normal tissues to determine the differentially expressed genes in gastric cancer tissues
Project description:In this dataset, we include the expression data obtained from gastric cancer tissues and gastric normal tissues to determine the differentially expressed genes in gastric cancer tissues.
Project description:In this dataset, we include the expression data obtained from gastric cancer tissues and gastric normal tissues to determine the differentially expressed microRNA in gastric cancer tissue.s
Project description:In this dataset, we include the expression data obtained from gastric cancer tissues and gastric normal tissues to determine the differentially expressed genes in gastric cancer tissues 10 tissues (5 paired of gastric cancer vs.normal tissues) were analysed. We generated the following pairwise comparisons:C1 VS.N1;C2 VS.N2;C3 VS.N3;C4 VS.N4;C5 VS.N5; genes with a fold-change ≥2 were selected
Project description:Gastric cancer is one of the most common malignant tumors. Asia has a high incidence of gastric cancer globally. South Korea, Mongolia, Japan and China are the four countries with the highest incidence of gastric cancer in the world. Gansu province in China has the estimated age-standardized incidence rates and mortality rates by Chinese standard population of 62.34/100,000 and 36.94/100,000, respectively, in 2012, which are much higher than the average level of China (22.06/100,000 and 15.16/100,000) in the same year. As a high incidence area of gastric cancer in China, Wuwei city in Gansu province has the prevalence of gastric cancer almost 5 times higher than the average level nationwide. In this study, the cancer tissues and matched adjacent normal mucosa tissues of 5 patients with early gastric cancers who were treated with ESD in Gansu Wuwei Tumor Hospital and the First Hospital of Lanzhou University were collected. All of the patients are from Gansu, China. MicroRNA array was used to find the differences in microRNAs expression profile between the early gastric cancer tissues and the para-cancer normal tissues. It is expected to explore the reasons of the abnormal high incidence of gastric cancer in Gansu Province, China, from the aspect of microRNAs expression profile characteristics.
Project description:We performed RNA-seq experiments to identify differentially expressed intergenic transcripts between gastric cancer and normal tissues/cells. Three primary cell culture samples from gastric cancer tissues, three gastric cancer cell lines and two normal tissue samples were used for the experiments.