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Differential Expression and Quantitative Analysis of H. congolense DSM 11287 Transcriptome in Biofilms

ABSTRACT: Differential Expression and Quantitative Analysis of H. congolense DSM 11287 Transcriptome in Biofilms

PROVIDER: PRJNA613491 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11353937_1.fastq.gz	Fastqsanger.gz
	SRR11353937_2.fastq.gz	Fastqsanger.gz
	SRR11353938_1.fastq.gz	Fastqsanger.gz
	SRR11353938_2.fastq.gz	Fastqsanger.gz
	SRR11353939_1.fastq.gz	Fastqsanger.gz

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Differential Expression and Quantitative Analysis of H. congolense DSM 11287 Transcriptome in Biofilms

Project description:Purpose: Evaluation of differential expression using Illumina HiSeq 2500 analysis of RNA of pure cultures of H. congolense grown in biofilms on various surfaces to assess the impact of surface type on transcriptome.

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Project description:Purpose: The is a major paucity of knowledge regarding the biology of Trypanosoma congolense, a protozoan parasite primarily responsible for Animal African Trypanosomiasis. In contrast, the closely related species T. brucei, is far better understood. To characterise core metabolism in T. congolense, comparative RNAseq analysis was undertaken to assess similarities and differences in transcript levels of genes associated with metabolism Methods: Samples from both in vitro culture and ex vivo (isolated from murine infections) bloodstream-form T. brucei and T. congolense were RNA-sequenced. Data was analyzed using a pipeline that allows for inter-species comparison Results: T. congolense exhibits increased transcript abundance in genes associated with the glycosomal succinate shunt, as well as mitochondrial metabolism, in particular the catabolism of pyruvate to acetate, compared to T. brucei. These differences occur both in vitro and ex vivo. Furthermore there are differences in nucleotide metabolism, and transcript levels of genes involved in fatty acid synthesis are reduced in T. congolense compared to T. brucei. Conclusions: Comparative RNAseq between two closely related species provided a detailed overview of similarities and differences in core metabolism. This carries significant implications for adaptation to in vitro culture, and drug efficacy, mode of action and mode of resistance.

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Expression analysis of strains Lactococcus lactis KCTC 3769T, L. raffinolactis DSM 20443T, L. plantarum DSM 20686T, L. fujiensis JSM 16395T, L. garvieae KCTC 3772T, L. piscium DSM 6634T and L. chungangensis CAU 28T

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