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Transcriptomic analysis of tumor infiltrating CD8+ T cells during PDAC progression

ABSTRACT: Transcriptomic analysis of tumor infiltrating CD8+ T cells during PDAC progression

PROVIDER: PRJNA614931 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11403774_1.fastq.gz	Fastqsanger.gz
	SRR11403774_2.fastq.gz	Fastqsanger.gz
	SRR11403775_1.fastq.gz	Fastqsanger.gz
	SRR11403775_2.fastq.gz	Fastqsanger.gz
	SRR11403776_1.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of tumor infiltrating CD8+ T cells during PDAC progression

Project description:CD8+ T cells are master effectors of anti-tumor immunity and their presence at tumor sites correlates with favorable outcomes. However, metabolic constraints imposed by the tumormicroenvironment can dampen their ability to control tumor progression. We will analyze the transcriptional profile of CD8+ T cells infiltrating murine tumors during progression in a pre-cinical model pancreatic ductal adenocarcinoma (PDA).

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Expression data from FACS-sorted CD8+BTLA+ vs CD8+BTLA- Human Tumor-infiltrating Lymphocytes in Metastatic Melanoma

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