Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genetic analysis of the modern Australian labradoodle dog breed reveals strong selection for poodle traits

ABSTRACT: Genetic analysis of the modern Australian labradoodle dog breed reveals strong selection for poodle traits

PROVIDER: PRJNA615393 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genetic analysis of the modern Australian labradoodle dog breed reveals strong selection for poodle traits

Project description:Allele frequency analysis reveals that the breed is enhanced for genes controlling traits associated with the poodle-type coat, which are perceived to have an association with hypoallergenicity, with no strong signatures of selection for Labrador retriever (LAB) traits. This study provides a blueprint for understanding how dog breeds are formed, highlighting the limited scope of trait selection in defining seemingly new breeds.

2020-07-17 | GSE147501 | GEO

Studies of modern Italian dog populations reveal multiple patterns for domestic breed evolution

Project description:Through thousands of years of breeding and strong human selection, the dog (Canis lupus familiaris) exists today within hundreds of closed populations throughout the world, each with defined phenotypes. A singular geographic region with broad diversity in dog breeds presents an interesting opportunity to observe potential mechanisms of breed formation. Italy claims 14 internationally recognized dog breeds, with numerous additional local varieties. To determine the relationship among Italian dog populations, we integrated genetic data from 263 dogs representing 23 closed dog populations from Italy, seven Apennine gray wolves. Using 142,840 genome-wide SNPs, this dataset was used in the identification of breed development routes for the Italian breeds that included divergence from common populations for a specific purpose, admixture of regional stock with that from other regions, and isolated selection of local stock with specific attributes.

2018-10-10 | GSE121027 | GEO

Canis lupus familiaris breed:Alaskan Sled Dog (Modern, 2010's)

Project description:Canis lupus familiaris breed:Alaskan Sled Dog (Modern, 2010's) Raw sequence reads

| PRJNA786528 | ENA

Genomic reconstruction of Galápagos dog history reveals strategies for management of an invasive species

Project description:Free-breeding dogs have occupied the Galápagos islands at least since the 1830s, however, it was not until the 1900s that dog populations grew substantially, endangering wildlife and spreading disease. In 1981, authorities sanctioned the culling of free-roaming dogs. Yet there are currently large free-roaming dog populations of unknown ancestry on the islands of Isabela and Santa Cruz, whose ancestry has never been assessed on a genome-wide scale. Thus, we performed a complete genomic analysis of the current Galápagos dog population as well as historical Galápagos dogs sampled between 1969 and 2003, testing for population structure, admixture, and shared ancestry. Our dataset included samples from 187 modern and six historical Galápagos dogs, together with whole genome sequence from over 2,000 modern purebred and village dogs. Our results indicate that modern Galápagos dogs are recently admixed with purebred dogs but show no evidence of a population bottleneck related to the culling. Additionally, IBD analyses reveal evidence of shared shepherd-dog ancestry in the historical Galápagos dogs. Overall, our results demonstrate that the 1980s culling of dogs was ineffective in controlling population size and did little to reduce genetic diversity, instead producing a stable and expanding population with genomic signatures of historical dogs remaining today. The insights from this study can be used to improve population control strategies for the Galápagos Islands and other endangered endemic communities worldwide.

2024-10-01 | GSE276576 | GEO

Genomic analyses reveal the influence of geographic origin, migration and hybridization on modern dog breed development

Project description:Analysis of genotypes at 150,000 SNPs reveals patterns of allele and haplotype sharing that describes the breed relationships and development of 161 breeds of dog.

2017-03-17 | GSE96736 | GEO

Studies of modern Italian dog populations reveal multiple patterns for domestic breed evolution

Project description:Studies of modern Italian dog populations reveal multiple patterns for domestic breed evolution

| PRJNA495376 | ENA

Agilent Microarray of South Australian bread wheat

Project description:Transcriptome of South Australian bread wheat under salt stress

2017-07-02 | E-MTAB-3270 | biostudies-arrayexpress

Gastric Cancer Subtyping (Australian Patient Cohort)

Project description:Genome-wide mRNA expression profiles of 70 primary gastric tumors from the Australian patient cohort. Like many cancers, gastric adenocarcinomas (gastric cancers) show considerable heterogeneity between patients. Thus, there is intense interest in using gene expression profiles to discover subtypes of gastric cancers with particular biological properties or therapeutic vulnerabilities. Identification of such subtypes could generate insights into the mechanisms of cancer progression or lay the foundation for personalized treatments. Here we report a robust gene-xpression-based clustering of a large collection of gastric adenocarcinomas from Singaporean patients [GSE34942 and GSE15459]. We developed and validated a classifier for the three subtypes in Australian patient cohort.

2012-07-05 | GSE35809 | GEO

Regulatory constraint and selection during human knee evolution drive modern osteoarthritis risk

Project description:The evolution of human bipedalism exposed the knee to unique biomechanical challenges, requiring changes in knee anatomy giving rise to the modern-day configuration. In order to better understand the relationship between derived knee morphology and the genetic factors associated with osteoarthritis risk, we performed epigenetic profiling of murine forelimb/hindlimb growth plates to identify regulatory elements shaping formation of specific knee structures, identifying signals of ancient positive selection upon which more recent genetic drift overlaps risk-associated loci. Our functional analyses of an osteoarthritis-risk variant within a reproducibly-associated locus establishes a novel model for studying this degenerative disease.

2020-04-16 | GSE122877 | GEO

Gastric Cancer Subtyping (Australian Patient Cohort)

2012-07-04 | E-GEOD-35809 | biostudies-arrayexpress