Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Next Generation Sequencing of 12 human platelet's miRNA for Alzheimer's disease study

ABSTRACT: Next Generation Sequencing of 12 human platelet's miRNA for Alzheimer's disease study

PROVIDER: PRJNA616243 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11448242.fastq.gz	Fastqsanger.gz
	SRR11448243.fastq.gz	Fastqsanger.gz
	SRR11448244.fastq.gz	Fastqsanger.gz
	SRR11448245.fastq.gz	Fastqsanger.gz
	SRR11448246.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Next Generation Sequencing of 12 human platelet's miRNA for Alzheimer's disease study

Project description:We obtained miRNA expression information from 12 human platelet samples using the NGS method. The patient group was divided into "Normal Young", "Normal Old" and "Alzheimer's disease". Twenty miRNAs whose expression gradually changed in 3 groups were selected. Among them, miR150-3p and miR150-5p were highly correlated with each other and had a high correlation with the patient's age. In addition, the expression of miR-150-3p and miR-150-5p showed a miRNA-imbalance phenomenon in which the ratio was specifically changed in Alzheimer's disease.

2020-04-24 | GSE147714 | GEO

Next-generation sequencing of wild type and 5XFAD transcriptomes for Alzheimer's disease study

Project description:Next-generation sequencing of wild type and 5XFAD transcriptomes for Alzheimer's disease study

| PRJNA597779 | ENA

Neuronal expression of Alzheimer's disease-associated FAD mouse genotype at 3/6/12 months

Project description:Neuronal expression of Alzheimer's disease-associated FAD mouse genotype at 3/6/12 months.

2019-12-04 | GSE140286 | GEO

A blood based 12-miRNA signature of Alzheimer patients

Project description:We applied Next-Generation Sequencing (NGS) to miRNAs from blood samples of 48 AD (Alzheimer's Disease) patients and 22 unaffected controls, yielding a total of 140 unique mature miRNAs with significantly changed expression level. Of these, 82 were higher and 58 lower abundant in samples from AD patients. We selected a panel of 12 miRNAs for a qRT-PCR analysis on a larger cohort of 202 samples including not only AD patients and healthy controls but also patients with other CNS illnesses: Multiple Sclerosis, Parkinson's Disease, Major Depression, Bipolar Disorder, Schizophrenia, and Mild Cognitive Impairment, which is assumed to represent a transitional period before the development of AD. MiRNA target enrichment analysis of the selected 12 miRNAs indicated an involvement of miRNAs in nervous system development, neuron projection, neuron projection development, and neuron projection morphogenesis, respectively. Using this 12-miRNA signature we were able to differentiate between AD and controls with an accuracy of 93.3%, a specificity of 95.1%, and a sensitivity of 91.5%. The differentiation of AD from other neurological diseases was possible with accuracies between 73.8% and 77.8%. The differentiation of the other CNS disorders from controls yielded even higher accuracies.

2013-06-17 | GSE46579 | GEO

Next generation sequence analysis

Project description:Next generation sequence analysis

| PRJNA560769 | ENA

A blood based 12-miRNA signature of Alzheimer patients

2013-06-17 | E-GEOD-46579 | biostudies-arrayexpress

Next generation sequencing based transcriptome comparison between wild-type Drosophila and an Alzheimer's disease model

Project description:Next generation sequencing based transcriptome comparison between wild-type Drosophila and an Alzheimer's disease model

| PRJNA431206 | ENA

Next Generation Sequencing Analysis of livers from 2-month WT/12-month WT and 2-month HKO/12-month nontumor/12month- tumor.

Project description:SRSF2 flanked with flox was specifically depleted in the livers by Alb-Cre(HKO),and took the intact ones as contorl(WT).Near 70% of the HKO livers spontaneously developed malignant tumors(took the tumor areas as tumor while the tumor-adjacent as nontumor).Then total RNAs of 2-month WT/HKO and 12-month WT/nontumor/tumor were isolated and performed the next generation sequencing. We profiled the gene expression regulated by Cre-loxp-mediated knockout system.

2020-05-05 | GSE130745 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of miRNA

Project description:Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare miRNA expressions of pear in two different conditions.

2017-01-26 | GSE80747 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of miRNA

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of miRNA

| PRJNA319909 | ENA