Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Targeting T-cell Lymphoma Epigenome Induces Cell Death, Cancer Testes Antigens, Immune Modulatory Signaling Pathways

ABSTRACT: Targeting T-cell Lymphoma Epigenome Induces Cell Death, Cancer Testes Antigens, Immune Modulatory Signaling Pathways

PROVIDER: PRJNA622991 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11477540_1.fastq.gz	Fastqsanger.gz
	SRR11477540_2.fastq.gz	Fastqsanger.gz
	SRR11477541_1.fastq.gz	Fastqsanger.gz
	SRR11477541_2.fastq.gz	Fastqsanger.gz
	SRR11477542_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

Targeting the T-Cell Lymphoma Epigenome Induces Cell Death, Cancer Testes Antigens, Immune-Modulatory Signaling Pathways.

Project description:The peripheral T-cell lymphomas (PTCL) could be considered the prototypical epigenetic disease. As a disease, they are uniquely sensitive to histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors, both alone and in combination, are characterized by a host of mutations in epigenetic genes, and can develop spontaneously in genetically engineered murine models predicated on established recurring mutations in (RHOAG17V) and TET2, an epigenetic gene governing DNA methylation. Given the clinical benefit of HDAC inhibitors (HDACi) and hypomethlyation agents alone and in combination in PTCL, we sought to explore a mechanistic basis for these agents in PTCL. Herein, we reveal profound class synergy between HDAC and DNMT inhibitors in PTCL, and that the combination induces degrees of gene expression that are substantially different and more extensive than that observed for the single agents. A prominent signature of the combination relates to the transcriptional induction of cancer testis antigens and genes involved in the immune response. Interestingly, TBX21 and STAT4, master regulators of TH1 differentiation, were among the genes upregulated by the combination, suggesting the induction of a TH1-like phenotype. Moreover, suppression of genes involved in cholesterol metabolism and the matrisome were also identified. We believe that these data provide a strong rationale for clinical studies, and future combinations leveraging an immunoepigenetic platform.

| S-EPMC8941846 | biostudies-literature

Targeting T-cell Lymphoma Epigenome Induces Cell Death, Cancer Testes Antigens, Immune Modulatory Signaling Pathways

Project description:We perform expression analysis on a panel of four T-cell lymphoma lines exposed to romidepsin and 5-azacytidine as single agent and combination.

2020-04-04 | GSE148069 | GEO

Lung Megakaryocytes are Immune Modulatory Cells

Project description:Lung Megakaryocytes are Immune Modulatory Cells

| PRJNA664993 | ENA

Modulatory role of skin microbiome against UV

Project description:Modulatory role of skin microbiome against UV

| PRJNA481877 | ENA

RBM46 in mouse testes.

Project description:RBM46 in mouse testes.

| PRJNA809660 | ENA

Transcriptional profiles of Drosophila melanogaster testes and seminal vesicles/testes terminal epithelium.

Project description:Testes and testes terminal epithelium/seminal vesicles were dissected and separated from 4-5 day old Oregon-R-modENCODE Drosophila melanogaster males. RNA-sequencing was then performed on these two distinct biological structures.

2017-04-20 | GSE80548 | GEO

Transcription profiling of Drosophila transformed with two Plasmodium cell surface antigens

Project description:Two Plasmodium cell surface antigens were transformed into Drosophila, un-induced flies were compared to induced flies.

2008-12-31 | E-MEXP-1859 | biostudies-arrayexpress

Modulatory profiling identifies mechanisms of small molecule-induced cell death.

Project description:Cell death is a complex process that plays a vital role in development, homeostasis, and disease. Our understanding of and ability to control cell death is impeded by an incomplete characterization of the full range of cell death processes that occur in mammalian systems, especially in response to exogenous perturbations. We present here a general approach to address this problem, which we call modulatory profiling. Modulatory profiles are composed of the changes in potency and efficacy of lethal compounds produced by a second cell death-modulating agent in human cell lines. We show that compounds with the same characterized mechanism of action have similar modulatory profiles. Furthermore, clustering of modulatory profiles revealed relationships not evident when clustering lethal compounds based on gene expression profiles alone. Finally, modulatory profiling of compounds correctly predicted three previously uncharacterized compounds to be microtubule-destabilizing agents, classified numerous compounds that act nonspecifically, and identified compounds that cause cell death through a mechanism that is morphologically and biochemically distinct from previously established ones.

| S-EPMC3182736 | biostudies-literature

Somatic mutation and clonal evolution in the human testes

Project description:In this study we aim to characterise the landscape of Pathogenic variants and clonal dynamics in normal and cancerous testes and their role in cancer predisposition. The study combines targeted sequencing and whole-genome sequencing of microbiopsies from testes. The range of patients studied will include healthy individuals, and patients with testicular cancer.

| EGAS00001003021 | EGA

Cas9 induced cell death

Project description:Saturation guide RNA loading overcomes Cas9-induced human cell death

| PRJEB21268 | ENA