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Loss of Musashi-1 inhibits breast cancer metastasis via regulation of Timp3/Mmp9

ABSTRACT: Loss of Musashi-1 inhibits breast cancer metastasis via regulation of Timp3/Mmp9

PROVIDER: PRJNA623199 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11484028_1.fastq.gz	Fastqsanger.gz
	SRR11484028_2.fastq.gz	Fastqsanger.gz
	SRR11484029_1.fastq.gz	Fastqsanger.gz
	SRR11484029_2.fastq.gz	Fastqsanger.gz
	SRR11484030_1.fastq.gz	Fastqsanger.gz

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Loss of Musashi-1 inhibits breast cancer metastasis via regulation of Timp3/Mmp9

Project description:To investigate the molecular mechanism of Msi1 in breast cancer metastasis, we performed transcriptome profiling at 16 weeks of primary tumor samples between ctrl and Msi1 cko mice, We performed a pathway enrichment analysis of the transcriptome data, the enriched KEGG pathways are mostly related to cellular adhesion, such as Focal adhesion, cell adhesion molecular (CAM), ECM-receptor interaction and regulation of actin cytoskeleton, which are closely related to the formation of invadopodia.

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Microarray analysis of differential gene expression of whole testis extracts from transgenic Musashi-2 and transgenic Musashi-1 over-expression mice

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Microarray analysis of differential gene expression of whole testis extracts from transgenic Musashi-2 and transgenic Musashi-1 over-expression mice

Project description:Analysis of testis-specific over-expression of Musashi-1 and Musashi-2 at gene expression level. The hypothesis tested in the present study was that testis-specific over-expression of Musashi-1/Musashi-2 would result in differential gene expression profiles from the Wildtype control. Results provide important information of the genes affected by Musashi-2 overexpression during spermatogenesis. Total RNA obtained from whole adult testis of transgenic testis-specfic Musashi-1 and Musashi-2 overexpression mice compared to Wildtype (control) littermates. 4 replicates, 16 samples, 2 comparisons: Wt (Musashi-1) vs. TgMsi1 & Wt (Musashi-2) vs. TgMsi2

2014-07-12 | E-GEOD-59358 | biostudies-arrayexpress

Low-Dose Carbon Monoxide Inhibits Cancer Metastasis

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PTEN phosphatase inhibits metastasis

Project description:PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose dysfunction has been implicated in melanomagenesis; less is known about how its phosphatases regulate melanoma metastasis. We show that PTEN expression negatively correlates with metastatic progression in human melanoma samples and a PTEN-deficient mouse melanoma model. Wildtype PTEN expression inhibited melanoma cell invasiveness and metastasis in a dose-dependent manner, behaviors that specifically required PTEN protein phosphatase activity. PTEN phosphatase activity regulated metastasis through Entpd5. Entpd5 knockdown reduced metastasis and IGF1R levels while promoting ER stress. In contrast, Entpd5 overexpression promoted metastasis and enhanced IGF1R levels, while reducing ER stress. Moreover, Entpd5 expression was regulated by the ER stress sensor ATF6. Altogether, our data show that PTEN phosphatase activity inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6, thereby identifying novel candidate therapeutic targets for the treatmtreatingwith PTEN mutant melanoma.

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Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes

Project description:RNA binding proteins (RBPs) are key regulators of normal and pathological gene expression. Small molecules targeting RBP-RNA interactions are a rapidly emerging class of therapeutics. Ro-08-2750 (Ro) was previously identified as a competitive inhibitor of Musashi-RNA interactions. Here we show Ro potently inhibits steroidogenesis and viability independent of Musashi-2 in multiple cell lines. We identified Ro-interacting proteins using an unbiased proteome-wide approach. Other RBPs were a prominent class of Ro-interacting proteins and leveraging large-scale ENCODE data we found a subset of these phenocopy Ro inhibition. We provide a general framework for validating the specificity and identifying targets of RBP inhibitors in a cellular context.

2022-09-14 | GSE213218 | GEO

Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis

Project description:This SuperSeries is composed of the following subset Series: GSE16432: MSI2 regulates hematopoiesis and accelerates leukemogenesis GSE22773: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible) GSE22774: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK) GSE22775: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines) Refer to individual Series

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