Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

How to Make an Elephant: Functional Genomic Divergence and the Evolution of Cancer Suppression

ABSTRACT: How to Make an Elephant: Functional Genomic Divergence and the Evolution of Cancer Suppression

PROVIDER: PRJNA623216 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11484175_1.fastq.gz	Fastqsanger.gz
	SRR11484175_2.fastq.gz	Fastqsanger.gz
	SRR11484176_1.fastq.gz	Fastqsanger.gz
	SRR11484176_2.fastq.gz	Fastqsanger.gz
	SRR11484177_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

How to Make an Elephant: Functional Genomic Divergence and the Evolution of Cancer Suppression

Project description:Contrast the genomes of different elephants species to find genetic differences underlying species differences like immune system differences that impact disease resistance.

2020-09-10 | GSE148098 | GEO

DNA Damage Response in Elephant Cells

Project description:The identity of most functional elements in the mammalian genome and the phenotypes they impact are unclear. Here, we perform a genome-wide comparative analysis of patterns of accelerated evolution in species with highly distinctive traits to discover candidate functional elements for clinically important phenotypes. We identify accelerated regions (ARs) in the elephant, hibernating bat, orca, dolphin, naked mole rat and thirteen-lined ground squirrel lineages in mammalian conserved regions, uncovering ~33,000 elements that bind hundreds of different regulatory proteins in humans and mice. ARs in the elephant, the largest land mammal, are uniquely enriched at elephant DNA damage response genes and changed conserved regulatory sites. The genomic hotspot for elephant ARs is the E3 ligase subunit of the Fanconi Anemia Complex, a master regulator of DNA repair. Additionally, ARs in the six species are associated with specific human clinical phenotypes that have apparent concordance with overt traits in each species.

2018-01-01 | GSE107117 | GEO

Elephant gut metagenome

Project description:Elephant gut microbiome

| PRJNA558043 | ENA

Regulatory divergence during limb evolution

Project description:Regulatory divergence during limb evolution

| PRJNA521485 | ENA

Characterisation of eggshell proteomes from the extinct Madagascar elephant bird

Project description:Characterisation of eggshell proteomes from the extinct Madagascar elephant bird

2023-01-20 | PXD035725 | Pride

The evolution of expression divergence in wild C. elegans

Project description:To examine the ways in which gene expression varies in natural populations and its relationship to genetic divergence, we estimated allele-specific expression in the offspring of multiple wild C. elegans strains crossed with the laboratory reference strain N2. Allele-specific expression analyses are uniquely sensitively able to identify cis regulatory changes, and coupled with analyses of differential expression between parental strains and parents and offspring can determine the regulatory pattern and inheritance mode of gene expression across the genome. We chose 7 strains that represented a range of divergence from N2 and spanned the species tree to cross with N2: EG4348; DL238; CB4856 (the classical ‘Hawaiian’ strain); ECA722; QX1211; and ECA701 and XZ1516 (two extremely diverged strains). This study sheds light on the relationship of genetic and expression divergence, the global patterns of inheritance and regulatory mode of genes in C. elegans, and the factors that differentiate genes with expression divergence from those with stabler expression.

2024-10-14 | GSE272616 | GEO

Molecular characterisation of adipose tissue in the African elephant (Loxodonta africana)

Project description:The African elephant (Loxodonta africana) is experiencing serious challenges to optimal reproduction in captivity. The physiological and molecular basis of this impaired fertility remains unknown. A functional link between nutritional status, body condition score and fertility is well established in humans and many other species, where adipose tissue production of the hormone leptin has emerged as a crucial reproductive regulator. This report forms the basis for future studies to address the effect of nutrient composition and body condition on captive and wild elephants.

2014-05-22 | E-MTAB-2024 | biostudies-arrayexpress

Project description:How to Make an Elephant

| PRJNA622303 | ENA

Regulatory divergence during pig limb evolution

Project description:Regulatory divergence during pig limb evolution

| PRJNA521488 | ENA

Regulatory divergence during mouse limb evolution

Project description:Regulatory divergence during mouse limb evolution

| PRJNA521487 | ENA