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Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop

ABSTRACT: Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop

PROVIDER: PRJNA623301 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11486331_1.fastq.gz	Fastqsanger.gz
	SRR11486331_2.fastq.gz	Fastqsanger.gz
	SRR11486332_1.fastq.gz	Fastqsanger.gz
	SRR11486332_2.fastq.gz	Fastqsanger.gz
	SRR11486333_1.fastq.gz	Fastqsanger.gz

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Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop

Project description:The secreted factor Nodal has been shown to be a major left determinant. Although it is associated with severe congenital heart defects, its role in heart morphogenesis has remained poorly understood. Here, we report that Nodal is transiently active in precursors of the mouse heart tube poles, before the morphological changes of heart looping. In conditional mutants, we show that Nodal is not required to initiate asymmetric morphogenesis. We provide evidence of a heart-specific random generator of asymmetry that is independent of Nodal. Using 3D quantifications and simulations, we demonstrate that Nodal functions as a bias of this mechanism: it is required to amplify and coordinate opposed left-right asymmetries at the heart tube poles, thus generating a robust helical shape. We identify downstream effectors of Nodal signalling, regulating asymmetries in cell proliferation, cell differentiation and extra-cellular matrix composition. Our work provides novel insight into how Nodal regulates asymmetric organogenesis.

2020-11-09 | GSE148123 | GEO

ZIC2 Is Required For Nodal Expression And The Establishment Of Left-Sided Identity

Project description:ZIC2 Is Required For Nodal Expression And The Establishment Of Left-Sided Identity

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Nodal

Project description:Mus musculus Nodal, nodal [Source:MGI Symbol;Acc:MGI:97359], is differentially expressed in 30 experiment(s);

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Nodal

Project description:Mus musculus Nodal, nodal [Source:MGI Symbol;Acc:MGI:97359], is expressed in 19 baseline experiment(s);

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NODAL

Project description:Monodelphis domestica NODAL, nodal growth differentiation factor [Source:NCBI gene;Acc:100023464], is expressed in 2 baseline experiment(s);

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Nodal

Project description:Rattus norvegicus Nodal, nodal growth differentiation factor [Source:RGD Symbol;Acc:1305994], is expressed in 1 baseline experiment(s);

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NODAL

Project description:Oryctolagus cuniculus NODAL, nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865], is expressed in 1 baseline experiment(s);

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NODAL

Project description:Homo sapiens NODAL, nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865], is expressed in 31 baseline experiment(s);

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Project description:Macaca mulatta NODAL, nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865], is expressed in 1 baseline experiment(s);

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NODAL

Project description:Homo sapiens NODAL, nodal growth differentiation factor [Source:HGNC Symbol;Acc:HGNC:7865], is differentially expressed in 49 experiment(s);

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