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Wee1 inhibition in acute lymphoblastic leukemia with MLL rearrangement.

ABSTRACT: Wee1 inhibition in acute lymphoblastic leukemia with MLL rearrangement.

PROVIDER: PRJNA623413 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11492208.fastq.gz	Fastqsanger.gz
	SRR11492209.fastq.gz	Fastqsanger.gz
	SRR11492210.fastq.gz	Fastqsanger.gz
	SRR11492211.fastq.gz	Fastqsanger.gz
	SRR11492212.fastq.gz	Fastqsanger.gz

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Wee1 inhibition in acute lymphoblastic leukemia with MLL rearrangement.

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Mechanistic study of Wee1 kinase inhibition with AZD1775 exposes drug targetable vulnerabilities in acute B-lymphoblastic leukemia [GROseq]

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Project description:This study characterized the effect of WEE1 kinase inhibition using AZD1775 treatment on single-cell accessible chromatin and gene expression profile using the 10x Genomics multiome protocol (ATAC + Gene Expression Assay) in the acute lymphoblastic leukemia cell line RS4;11 that represents the KMT2A-rearranged subtype.

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Mechanistic study of Wee1 kinase inhibition with AZD1775 exposes drug targetable vulnerabilities in acute B-lymphoblastic leukemia [scRNA-seq PDX MLL-7]

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The Methylome Landscape of Infant B-cell precursor Acute Lymphoblastic Leukemia (iB-ALL)

Project description:B-cell acute lymphoblastic leukemia (B-ALL) is the most prevailing childhood cancer. As predicated by its prenatal origin, infant B-ALL (iB-ALL) show a silent mutational landscape irrespective of the MLL rearrangement/status, suggesting that other regulatory mechanisms might be impaired in the context of the disease. Here we used the most recent Illumina MethylationEPIC Beadchip platform to describe the genome-wide DNA methylation changes observed in a total of 69 de novo MLL-AF4+, MLL-AF9+ and non-rearranged MLL iB-ALL leukemias uniformly treated according to Interfant 99/06 protocol. Please note that samples X8 and X9 (pool of B cells and BCP) correspond to samples 200340580160_R08C01 and 200340580161_R07C01 from study E-MTAB-6315, respectively.

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