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Finding two synergized compounds from Chinese herbal medicine in rheumatoid arthritis therapy

ABSTRACT: Finding two synergized compounds from Chinese herbal medicine in rheumatoid arthritis therapy

PROVIDER: PRJNA625107 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11541100_1.fastq.gz	Fastqsanger.gz
	SRR11541100_2.fastq.gz	Fastqsanger.gz
	SRR11541101_1.fastq.gz	Fastqsanger.gz
	SRR11541101_2.fastq.gz	Fastqsanger.gz
	SRR11541102_1.fastq.gz	Fastqsanger.gz

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Finding two synergized compounds from Chinese herbal medicine in rheumatoid arthritis therapy

Project description:Purpose: To search candidate synergized compounds from Chinese herbal medicine used in RA therapy Methods: Candidate synergized compounds were searched based on multi-information integrative approaches. In vivo experiment in collagen induced arthritis rat was then carried out to evaluate the efficacy and synergism of compounds combination treatment. RNA sequencing and IPA were used to investigate the synergized mechanism of combination treatment. Results: We found a pair of compound combination which could alleviate the symptom of CIA rats. RNA sequencing and IPA analysis revealed that the synergistic mechanism of combination treatment was related to several canonical signaling pathways and key targets LTA, CD83 and SREBF1. Conclusion: A pair of compound combination has been found. RNA sequencing and IPA analysis revealed that the synergistic mechanism of combination treatment was related to several canonical signaling pathways and key targets.

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Project description:Personalized therapy of rheumatoid arthritis (RA) based on traditional Chinese medicine cold and hot syndromes is selection of the best treatment for an individual patient. Wutou Decoction (WTD) is one of the classic Chinese herbal formulae which achieve favorable therapeutic response in treating RA-cold syndrome. Microarray analysis based on the adjuvant induced arthritis model combined with characteristics of RA and cold/hot syndromes was performed to screen RA-cold and RA-hot-syndrome-related genes, as well as WTD effect genes.

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