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Genome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells

ABSTRACT: Genome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells

PROVIDER: PRJNA625322 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11546771_1.fastq.gz	Fastqsanger.gz
	SRR11546771_2.fastq.gz	Fastqsanger.gz
	SRR11546772_1.fastq.gz	Fastqsanger.gz
	SRR11546772_2.fastq.gz	Fastqsanger.gz
	SRR11546773_1.fastq.gz	Fastqsanger.gz

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Genome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells

Project description:Genetic variants in IRF5 are associated with multiple immune-mediated diseases. IRF5 has been predominantly focused on for its regulation of myeloid-derived cells. We found that IRF5 contributes to CD4+ T cell outcomes and that it regulates early T cell receptor-initiated signaling and subsequently translocates to the nucleus where it binds to promoters of various genes regulated with T cell activation. We report the chromatin state of freshly isolated and activated IRF5+/+ and IRF5-/- CD4+ T cells in vitro. While there are minimal differential peaks between freshly isolated IRF5+/+ and IRF5-/- CD4+ T cells, once activated multiple differential peaks are observed between IRF5+/+ and IRF5-/- CD4+ T cells.

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